Electrophysiologic assessment of photoreceptor function in patients with primary open-angle glaucoma

Karen Holopigian, Vivienne C. Greenstein, William Seiple, Donald C. Hood, Robert Ritch

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Purpose: Electroretinograms to high-intensity flashes were obtained to determine the extent of rod and cone photoreceptor and postreceptor dysfunction in patients with primary open-angle glaucoma. Methods: Full-field flash electroretinograms were obtained using brief high-intensity flashes. Dark-adapted (rod-dominated) and light-adapted (cone-dominated) electroretinogram responses were recorded to a "white" light as a function of flash intensity. The a-wave data were fitted with a model based on photopigment transduction to obtain values for the parameters of log Rmax (the maximum response) and log S (sensitivity). Oscillatory potentials were measured to the cone-dominated high-intensity flashes. Standard clinical 30 Hz flicker electroretinogram responses were recorded using a Grass photostimulator. Results: Analysis of rod and cone a-wave data showed that log Rmax and log S values were within the normal range in nearly all of the patients. For some patients, oscillatory potentials were delayed beyond the normal range. Conclusion: Our results provide little evidence for widespread photoreceptor abnormalities in primary open-angle glaucoma.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalJournal of Glaucoma
Issue number2
StatePublished - Apr 2000
Externally publishedYes


  • Electroretinogram
  • Glaucoma
  • Oscillatory potentials
  • Photoreceptors


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