Abstract
The effects of several components of ophthalmic preparations on isolated rabbit corneas were studied by continuous electrophysiologic monitoring followed by fixation for scanning electron microscopy (SEM) Benzalkonium chloride (0.001 percent), thimerosal (0.0004 percent), and amphotericin B (0.0025 percent) all briefly increased ion transport, then greatly decreased epithelial resistance. Severe disruption of surface cell layers occurred simultaneously with resistance decrease. Silver nitrate (0.00017 percent) stimulated transport with less accompanying morphologic damage. Tetracaine (0.05 percent) disrupted epithelial function and caused exfoliation of several cell layers. Chlorobutanol (0.1 percent) produced a nearly complete loss of the squamous cell layer. Chloramphenicol, epinephrine, and pilocarpine produced minor changes in structure and electrophysiology at full clinical concentration. It was concluded that properties of the corneal epithelium.
| Original language | English |
|---|---|
| Pages (from-to) | 899-911 |
| Number of pages | 13 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 16 |
| Issue number | 10 |
| State | Published - 1977 |
| Externally published | Yes |