Electron microscopic localization of factor-VIII-related antigen in adult human blood vessels

J. H. Rand, R. E. Gordon, I. I. Sussman, S. V. Chu, V. Solomon

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

We have localized factor-VIII-related antigen, using immunofluorescence and electron microscopy, in adult human blood vessels. In addition to its presence in endothelial cells, the antigen was localized within subendothelium and the layers of elastic lamina closest to the lumen. Also, we provide the first morphological evidence that factor-VIII-related antigen is associated with collagen fibrils within the vessel wall. The studies suggest that this subendothelial factor-VIII-related antigen may play a role in the adhesion of platelets to subendothelial components following endothelial injury.

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalUnknown Journal
Volume60
Issue number3
DOIs
StatePublished - 1982
Externally publishedYes

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