TY - JOUR
T1 - Elastin Degradation and Lung Function Deterioration with Remote Secondhand Tobacco Smoke Exposure in Never-smokers
AU - Rakic, Jelena Mustra
AU - Zeng, Siyang
AU - Rohdin-Bibby, Linnea
AU - Van Blarigan, Erin L.
AU - Liu, Xingjian
AU - Ma, Shuren
AU - Kane, John P.
AU - Redberg, Rita F.
AU - Turino, Gerard M.
AU - Stock, Eveline Oestreicher
AU - Arjomandi, Mehrdad
N1 - Funding Information:
Abbreviations: secondhand smoke, SHS; elastin degradation markers, EDM; parameter estimate, PE; confidence interval, CI; forced expiratory volume in 1 second, FEV1; forced vital capacity, FVC; forced expiratory flow rate between 25% and 75%, FEF25%-75%; chronic obstructive pulmonary disease, COPD; dsemosine and isodesmosine, DI; Multicenter Ozone Study of oldER Subjects, MOSES; Flight Attendant Medical Research Institute, FAMRI; University of California San Francisco, UCSF; University of Rochester Medical Center, URMC; University of North Carolina, UNC; cellulose fiber, CF; pulmonary function test, PFTs; diffusing capacity, DCO; functional residual capacity, FRC; Global Lung Initiative, GLI; Global initiative for chronic Obstructive Lung Disease, GOLD; standard deviation, SD; body mass index, BMI; lower limit of normal, LLN Funding Support: This work was supported by: the Flight Attendant Medical Research Institute (FAMRI) (012500WG and CIA190001 to MA; CIA150034 to GMT; FAMRI Center of Excellence Award#012500 to RR); the California Tobacco-Related Disease Research Program (TRDRP) (T29IR0715 to MA); the Department of Veterans Affairs (CXV-00125 to MA); a National Library of Medicine Training Grant (NIH: T15LM007442 to SZ); Postdoctoral Training in Tobacco Control Research (NIH/NCI: T32 CA113710 to JMR); the Greenwall Foundation and Arnold Ventures (to RR); the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) (to RR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The statements and conclusions in this publication are those of the authors and not necessarily those of the funding agency. The mention of commercial products, their source, or their use in connection with the material reported herein is not to be construed as an actual or implied endorsement of such products. Date of Acceptance: June 8, 2022 | Published Online Date: June 13, 2022 Citation: MustraRakic J, Zeng S, Rohdin-Bibby L, et al. Elastin degradation and lung function deterioration with remote secondhand tobacco smoke exposure in never-smokers. Chronic Obstr Pulm Dis. 2022;9(3):377-393. doi: https://doi.org/10.15326/jcopdf.2022.0289
Publisher Copyright:
Copyright 2022, Journal of Iranian Medical Council. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: Prolonged past exposure to secondhand tobacco smoke (SHS) in never-smokers is associated with abnormal lung function and reduced diffusing capacity suggestive of an associated lung tissue injury and damage. The mechanisms by which past SHS exposure may contribute to lung tissue damage are unknown. Elastin is a major constituent of extracellular matrix in lung parenchyma. Objective: To determine whether past exposure to SHS is associated with ongoing lung tissue damage as indicated by elevated elastin degradation products that are linked to lung function. Methods: We measured the plasma levels of elastin degradation markers (EDM) from 193 never-smoking flight attendants with a history of remote SHS exposure in aircraft cabins and 103 nonsmoking flight attendants or sea-level control participants without such history of cabin SHS exposure and examined those levels versus their lung function with adjustment for covariates. The cabin SHS exposure was estimated based on airline employment history and years of the smoking ban enactment. Results: The median [interquartile range] plasma EDM level for all participants was 0.30 [0.24-0.36]ng/mL with a total range of 0.16-0.65ng/mL. Plasma EDM levels were elevated in those with a history of exposure to cabin SHS compared to those not exposed (0.33±0.08 versus 0.26±0.06ng/mL; age- and sex-adjusted P<0.001). In those with a history of cabin SHS exposure, higher EDM levels were associated with a lower diffusing capacity (parameter estimate [PE] 95% [confidence interval (CI)]=4.2 [0.4-8.0] %predicted decrease per 0.1ng/mL increase in EDM; P=0.030). Furthermore, EDM levels were inversely associated with forced expiratory volume in 1 second (FEV1), FEV1 to forced vital capacity (FVC) ratio, and forced expiratory flow rate between 25% and 75% (FEF25%-75%) (PE [95%CI]=5.8 [2.1-9.4], 4.0 [2.2-5.7], and 12.5 [5.8-19.2] %predicted decrease per 0.1ng/mL increase in EDM, respectively; P<0.001). Plasma EDM mediated a substantial fraction of the association of SHS with FEV1, FVC, and FEF25%-75% (P<0.05). Conclusions: Long after past exposure to SHS, there is ongoing elastin degradation beyond what is expected from the aging process, which likely contributes to lower lung function and a reduced pulmonary capillary bed as seen in chronic obstructive pulmonary disease (COPD).
AB - Background: Prolonged past exposure to secondhand tobacco smoke (SHS) in never-smokers is associated with abnormal lung function and reduced diffusing capacity suggestive of an associated lung tissue injury and damage. The mechanisms by which past SHS exposure may contribute to lung tissue damage are unknown. Elastin is a major constituent of extracellular matrix in lung parenchyma. Objective: To determine whether past exposure to SHS is associated with ongoing lung tissue damage as indicated by elevated elastin degradation products that are linked to lung function. Methods: We measured the plasma levels of elastin degradation markers (EDM) from 193 never-smoking flight attendants with a history of remote SHS exposure in aircraft cabins and 103 nonsmoking flight attendants or sea-level control participants without such history of cabin SHS exposure and examined those levels versus their lung function with adjustment for covariates. The cabin SHS exposure was estimated based on airline employment history and years of the smoking ban enactment. Results: The median [interquartile range] plasma EDM level for all participants was 0.30 [0.24-0.36]ng/mL with a total range of 0.16-0.65ng/mL. Plasma EDM levels were elevated in those with a history of exposure to cabin SHS compared to those not exposed (0.33±0.08 versus 0.26±0.06ng/mL; age- and sex-adjusted P<0.001). In those with a history of cabin SHS exposure, higher EDM levels were associated with a lower diffusing capacity (parameter estimate [PE] 95% [confidence interval (CI)]=4.2 [0.4-8.0] %predicted decrease per 0.1ng/mL increase in EDM; P=0.030). Furthermore, EDM levels were inversely associated with forced expiratory volume in 1 second (FEV1), FEV1 to forced vital capacity (FVC) ratio, and forced expiratory flow rate between 25% and 75% (FEF25%-75%) (PE [95%CI]=5.8 [2.1-9.4], 4.0 [2.2-5.7], and 12.5 [5.8-19.2] %predicted decrease per 0.1ng/mL increase in EDM, respectively; P<0.001). Plasma EDM mediated a substantial fraction of the association of SHS with FEV1, FVC, and FEF25%-75% (P<0.05). Conclusions: Long after past exposure to SHS, there is ongoing elastin degradation beyond what is expected from the aging process, which likely contributes to lower lung function and a reduced pulmonary capillary bed as seen in chronic obstructive pulmonary disease (COPD).
KW - biomarkers
KW - desmosine/isodesmosine
KW - flight attendants
KW - lung damage
KW - secondhand tobacco smoke exposure
UR - http://www.scopus.com/inward/record.url?scp=85136297889&partnerID=8YFLogxK
U2 - 10.15326/jcopdf.2022.0289
DO - 10.15326/jcopdf.2022.0289
M3 - Article
AN - SCOPUS:85136297889
SN - 2372-952X
VL - 9
SP - 377
EP - 393
JO - Chronic Obstructive Pulmonary Diseases
JF - Chronic Obstructive Pulmonary Diseases
IS - 3
ER -