TY - JOUR
T1 - Elastic light-scattering spectroscopy for discrimination of Benign from malignant disease in Thyroid nodules
AU - Suh, Hyunsuk
AU - A'Amar, Ousama
AU - Rodriguez-Diaz, Eladio
AU - Lee, Stephanie
AU - Bigio, Irving
AU - Rosen, Jennifer E.
N1 - Funding Information:
ACKNOWLEDGMENT The authors gratefully acknowledge Dr. David McAneny, who contributed materially through both his participation as a clinical investigator and in critically reviewing our proposal along with our surgical colleagues, who allowed their patients to be recruited for this trial, as well as our patients for their study participation. The author (JER) also gratefully acknowledges the Tauber Family Foundation for their support via an unrestricted endowment for the Laszlo N. Tauber Assistant Professorship.
PY - 2011/5
Y1 - 2011/5
N2 - Background: Thyroid cancer is the most common endocrine malignancy. The current standard of diagnosis, fine-needle aspiration biopsy, yields approximately 10-25% of indeterminate results leading to twice as many thyroidectomies for further diagnosis. Elastic scattering spectroscopy (ESS) is a new, minimally invasive optical-biopsy technique mediated by fiber-optic probes that is sensitive to cellular and subcellular morphological features. We assessed the diagnostic potential of ESS in the thyroid to differentiate benign from malignant thyroid nodules as determined by histology. Methods: Under an IRB approved protocol, 36 surgical patients (n = 21 benign thyroid nodules, n = 15 malignant tumors) had collection of ESS data from their fresh ex vivo thyroidectomy specimens. Using surgical pathology as our gold standard, spectral analyses were performed using a training set; these data were used to assess the ESS diagnostic potential using the leave-one-out technique. Results: Our test set was 75% sensitive and 95% specific in differentiating benign from malignant thyroid lesions, with a positive predictive value (PPV) of 0.92 and a negative predictive value (NPV) of 0.83. Conclusions: The ESS can accurately distinguish benign vs malignant thyroid lesions with high PPV and NPV. With further validation ESS could potentially be used as an in situ real-time diagnostic tool or as an adjunct to conventional cytology.
AB - Background: Thyroid cancer is the most common endocrine malignancy. The current standard of diagnosis, fine-needle aspiration biopsy, yields approximately 10-25% of indeterminate results leading to twice as many thyroidectomies for further diagnosis. Elastic scattering spectroscopy (ESS) is a new, minimally invasive optical-biopsy technique mediated by fiber-optic probes that is sensitive to cellular and subcellular morphological features. We assessed the diagnostic potential of ESS in the thyroid to differentiate benign from malignant thyroid nodules as determined by histology. Methods: Under an IRB approved protocol, 36 surgical patients (n = 21 benign thyroid nodules, n = 15 malignant tumors) had collection of ESS data from their fresh ex vivo thyroidectomy specimens. Using surgical pathology as our gold standard, spectral analyses were performed using a training set; these data were used to assess the ESS diagnostic potential using the leave-one-out technique. Results: Our test set was 75% sensitive and 95% specific in differentiating benign from malignant thyroid lesions, with a positive predictive value (PPV) of 0.92 and a negative predictive value (NPV) of 0.83. Conclusions: The ESS can accurately distinguish benign vs malignant thyroid lesions with high PPV and NPV. With further validation ESS could potentially be used as an in situ real-time diagnostic tool or as an adjunct to conventional cytology.
UR - http://www.scopus.com/inward/record.url?scp=79955869949&partnerID=8YFLogxK
U2 - 10.1245/s10434-010-1452-y
DO - 10.1245/s10434-010-1452-y
M3 - Article
C2 - 21174158
AN - SCOPUS:79955869949
SN - 1068-9265
VL - 18
SP - 1300
EP - 1305
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 5
ER -