@article{bce1c777d0e046c989089b744a2bcbfd,
title = "Egg hypersensitivity and adverse reactions to measles, mumps, and rubella vaccine",
abstract = "We evaluated the safety of the measles-mumps-rubella (MMR) combination vaccine in 140 children with egg hypersensitivity. All children, regardiess of vaccine skin test results or severity of egg hypersensitivity, were safely immunized with the MMR vaccine. Systemic reactions to MMR vaccine in two nonallergic children were documented, indicating that reactions unrelated to egg protein can occur. With the use of a competitive enzyme-linked immunosorbent assay, the standard MMR injection was found to contain approximately 37 pg of ovalbumin-like material. This study provides 95% confidence that at least 97.5% of egg-allergic children will tolerate MMR vaccine without significant difficulty. Skin testing was not found to be helpful in predicting an adverse reaction. We recommend that the American Academy of Pediatrics consider revising its current policy regarding skin test response to MMR vaccine and administration of MMR vaccine to egg-allergic children.",
author = "Fasano, {Mary Beth} and Wood, {Robert A.} and Cooke, {Sara K.} and Sampson, {Hugh A.}",
note = "Funding Information: In view of the exquisite sensitivity of some persons to egg protein, there has been long-standing concern about the safety of egg-derived vaccines in such persons. The viruses used in currently available individual measles and mumps vaccines, as well as the more Widely used measles-mumps-rubella combination vaccine, are prepared in cell cultures of chick embryo fibroblasts. Although these vaccines contain detectable amounts of egg-related antigens, the amounts are far less than in the egg-derived vaccines, and several reports have suggested that these vaccines are safe in egg-allergic children. 1-7 Current recommendations by the American Academy of Pediatrics (AAP) in the Report of the Committee on Infectious Diseases (Red Book) state that the MMR vaccine should be withheld from children with a history of signifi- Supported in part (Dr. Fasano) by the Harriet Lane Fellowship, by grant No. AI24439 (Dr. Sampson), from the National Institute of Allergy and Infections Diseases, and by grant No. RR-00052 from the General Clinical Research Centers Program. Submitted for publication Sept. 27, I99l; accepted Dec. 16, 1991. Reprint requests: Hugh A. Sampson, MD, Division of Pediatric Allergy/Immunology, CMSC 1103, Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205. 9/20/35836 cant systemic reactions after egg ingestion (hypotension, urticaria, shock, wheezing, laryngospasm) until puncture and intradermal skin test responses to the vaccine have been documented to be negative. For children with positive reactions to the vaccine, a series of graded injections with the vaccine is then recommended to confer protection, s Our experience, as well as that of others, indicates that revision of",
year = "1992",
month = jun,
doi = "10.1016/S0022-3476(05)81953-5",
language = "English",
volume = "120",
pages = "878--881",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Elsevier Inc.",
number = "6",
}