Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance

Christopher W. Seibert; Saad Rahmat; Florian Krammer; Peter Palese; Nicole M. Bouvier

doi:10.1128/JVI.00151-12

Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance

Christopher W. Seibert, Saad Rahmat, Florian Krammer, Peter Palese, Nicole M. Bouvier

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.

Original language	English
Pages (from-to)	5386-5389
Number of pages	4
Journal	Journal of Virology
Volume	86
Issue number	9
DOIs	https://doi.org/10.1128/JVI.00151-12
State	Published - May 2012

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abstract = "The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.",

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AB - The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.

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Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance

Abstract

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