Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance

Christopher W. Seibert, Saad Rahmat, Florian Krammer, Peter Palese, Nicole M. Bouvier

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.

Original languageEnglish
Pages (from-to)5386-5389
Number of pages4
JournalJournal of Virology
Volume86
Issue number9
DOIs
StatePublished - May 2012

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