Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling

Xiaobao Yang; Li Zhu; Yuedong Zhou; Zhong Li; Hongbin Zhai

doi:10.1055/s-2008-1072576

Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling

Xiaobao Yang
, Li Zhu
, Yuedong Zhou
, Zhong Li
, Hongbin Zhai

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A convenient synthesis of monosubstituted 3-alkynyl-furans by Suzuki coupling reaction of 3-furanylboronic acid with substituted acetylene bromides is described. The internal alkyne products were attainable in 50-89% yields from substrates free of relatively acidic protons. Our protocol is expected to find applications in the synthesis of structurally related natural products.

Original language	English
Pages (from-to)	1729-1732
Number of pages	4
Journal	Synthesis
Issue number	11
DOIs	https://doi.org/10.1055/s-2008-1072576
State	Published - 2 Jun 2008
Externally published	Yes

Keywords

3-Furanylboronic acid
Bromoalkynes
Monosubstituted 3-alkynylfurans
Suzuki coupling

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10.1055/s-2008-1072576

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title = "Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling",

abstract = "A convenient synthesis of monosubstituted 3-alkynyl-furans by Suzuki coupling reaction of 3-furanylboronic acid with substituted acetylene bromides is described. The internal alkyne products were attainable in 50-89\% yields from substrates free of relatively acidic protons. Our protocol is expected to find applications in the synthesis of structurally related natural products.",

keywords = "3-Furanylboronic acid, Bromoalkynes, Monosubstituted 3-alkynylfurans, Suzuki coupling",

author = "Xiaobao Yang and Li Zhu and Yuedong Zhou and Zhong Li and Hongbin Zhai",

year = "2008",

month = jun,

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doi = "10.1055/s-2008-1072576",

language = "English",

pages = "1729--1732",

journal = "Synthesis",

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T1 - Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling

AU - Yang, Xiaobao

AU - Zhu, Li

AU - Zhou, Yuedong

AU - Li, Zhong

AU - Zhai, Hongbin

PY - 2008/6/2

Y1 - 2008/6/2

N2 - A convenient synthesis of monosubstituted 3-alkynyl-furans by Suzuki coupling reaction of 3-furanylboronic acid with substituted acetylene bromides is described. The internal alkyne products were attainable in 50-89% yields from substrates free of relatively acidic protons. Our protocol is expected to find applications in the synthesis of structurally related natural products.

AB - A convenient synthesis of monosubstituted 3-alkynyl-furans by Suzuki coupling reaction of 3-furanylboronic acid with substituted acetylene bromides is described. The internal alkyne products were attainable in 50-89% yields from substrates free of relatively acidic protons. Our protocol is expected to find applications in the synthesis of structurally related natural products.

KW - 3-Furanylboronic acid

KW - Bromoalkynes

KW - Monosubstituted 3-alkynylfurans

KW - Suzuki coupling

UR - https://www.scopus.com/pages/publications/45249121520

U2 - 10.1055/s-2008-1072576

DO - 10.1055/s-2008-1072576

M3 - Article

AN - SCOPUS:45249121520

SN - 0039-7881

SP - 1729

EP - 1732

JO - Synthesis

JF - Synthesis

IS - 11

ER -

Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling

Abstract

Keywords

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