Efficient synthesis of beetle aggregation pheromone frontalin and its analogues

Xiaobao Yang, Shengjun Luo, Chengwen Hua, Hongbin Zhai

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


(-)-Frontalin is an aggregation pheromone that has found application in selective exterminating of certain harmful insects. This paper discloses an expedite synthesis of (±)-frontalin from a symmetric molecule, 2,6-dimethyl-1,6-heptadiene, in 64% yield. The one-flask operation consists of double dihydroxylation, mono-cleavage, and acid-catalyzed intramolecular acetalation. Our unique strategy was also successfully applied to additional diene substrates such as 4a and 4b.

Original languageEnglish
Pages (from-to)8551-8553
Number of pages3
Issue number43
StatePublished - 20 Oct 2003
Externally publishedYes


  • Aggregation pheromone
  • Double dihydroxylation
  • Frontalin
  • Intramolecular acetalation
  • Synthesis


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