TY - JOUR
T1 - Efficacy of Ultrasound-Guided Glenohumeral Joint Injections of Leukocyte-Poor Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Glenohumeral Osteoarthritis
T2 - A Randomized, Double-Blind Controlled Trial
AU - Kirschner, Jonathan S.
AU - Cheng, Jennifer
AU - Creighton, Andrew
AU - Santiago, Kristen
AU - Hurwitz, Nicole
AU - Dundas, Mark
AU - Beatty, Nicholas
AU - Kingsbury, Dallas
AU - Konin, Gabrielle
AU - Abutalib, Zafir
AU - Chang, Richard
N1 - Funding Information:
Supported by the Richard ERF Materson New Investigator Grant from the Foundation for PM&R (to J. Kirschner) and Harvest–Terumo BCT (donation of kits). REDCap use was supported by grant number UL1TR002384 from the National Center for Advancing Translational Sciences of the National Institutes of Health.
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Objective:To compare the efficacy of ultrasound-guided hyaluronic acid (HA) versus leukocyte-poor platelet-rich plasma (LP-PRP) injection in the treatment of glenohumeral osteoarthritis.Design:Double-blind randomized controlled trial.Setting:Academic institution.Patients:Seventy patients with chronic glenohumeral osteoarthritis were randomly assigned to receive a single injection of HA (n = 36) or LP-PRP (n = 34).Interventions:Leukocyte-poor platelet-rich plasma was processed using Harvest/TerumoBCT Clear PRP kits. Ultrasound-guided injections of 6 mL HA or 6 mL LP-PRP into the glenohumeral joint were performed. Patients, the injecting physician, and outcomes assessor were blinded to treatment assignments.Main outcome measures:Shoulder Pain and Disability Index (SPADI), American Shoulder and Elbow Surgeons (ASES) score, current/average numerical rating scale (NRS) pain scores, satisfaction, and side effects were assessed at the 5 follow-up time points over 12 months.Results:Baseline characteristics were similar between groups. There were no significant between-group differences regarding SPADI, ASES, and current/average NRS pain scores at any time point up to 12 months postinjection (P > 0.05). However, significant improvements in SPADI, ASES, and current/average NRS pain scores were observed in both groups starting at 1 or 2 months (P < 0.01, P < 0.01, P < 0.001, and P < 0.01, respectively). These improvements were observed regardless of osteoarthritis severity. For patients who received LP-PRP, there was no effect of platelet yield on outcomes. Side effect and satisfaction rates were similar between groups.Conclusions:There were no differences in pain and functional outcomes after a single injection of LP-PRP versus HA. However, significant improvements in pain and function were observed after both treatments in patients with glenohumeral osteoarthritis.
AB - Objective:To compare the efficacy of ultrasound-guided hyaluronic acid (HA) versus leukocyte-poor platelet-rich plasma (LP-PRP) injection in the treatment of glenohumeral osteoarthritis.Design:Double-blind randomized controlled trial.Setting:Academic institution.Patients:Seventy patients with chronic glenohumeral osteoarthritis were randomly assigned to receive a single injection of HA (n = 36) or LP-PRP (n = 34).Interventions:Leukocyte-poor platelet-rich plasma was processed using Harvest/TerumoBCT Clear PRP kits. Ultrasound-guided injections of 6 mL HA or 6 mL LP-PRP into the glenohumeral joint were performed. Patients, the injecting physician, and outcomes assessor were blinded to treatment assignments.Main outcome measures:Shoulder Pain and Disability Index (SPADI), American Shoulder and Elbow Surgeons (ASES) score, current/average numerical rating scale (NRS) pain scores, satisfaction, and side effects were assessed at the 5 follow-up time points over 12 months.Results:Baseline characteristics were similar between groups. There were no significant between-group differences regarding SPADI, ASES, and current/average NRS pain scores at any time point up to 12 months postinjection (P > 0.05). However, significant improvements in SPADI, ASES, and current/average NRS pain scores were observed in both groups starting at 1 or 2 months (P < 0.01, P < 0.01, P < 0.001, and P < 0.01, respectively). These improvements were observed regardless of osteoarthritis severity. For patients who received LP-PRP, there was no effect of platelet yield on outcomes. Side effect and satisfaction rates were similar between groups.Conclusions:There were no differences in pain and functional outcomes after a single injection of LP-PRP versus HA. However, significant improvements in pain and function were observed after both treatments in patients with glenohumeral osteoarthritis.
KW - glenohumeral osteoarthritis
KW - hyaluronic acid
KW - pain
KW - platelet-rich plasma
KW - shoulder
UR - http://www.scopus.com/inward/record.url?scp=85140803269&partnerID=8YFLogxK
U2 - 10.1097/JSM.0000000000001029
DO - 10.1097/JSM.0000000000001029
M3 - Article
C2 - 35316820
AN - SCOPUS:85140803269
SN - 1050-642X
VL - 32
SP - 558
EP - 566
JO - Clinical Journal of Sport Medicine
JF - Clinical Journal of Sport Medicine
IS - 6
ER -