Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease

J. M. Rabey, P. Nissipeanu, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review

141 Scopus citations

Abstract

Memantine is a 1-amino-adamantane derivative which has been proposed to be useful in the treatment of Parkinson's disease. Its beneficial effect has been related to its novel properties as an NMDA receptor blocker which can neutralize the effect of glutamate at striatal and subthalamic levels. In the present study, conducted in an open-fashion, 14 parkinsonian patients with motor fluctuations taking L-dopa, were given a supplement of memantine 30 mg/day. After one month, 10 patients completed the treatment (4 discontinued it due to abdominal pain, psychomotor agitation, confusion and dizziness). In 5 patients, the main parkinsonian features improved significantly (1 point or more on the Webster scale). In 6 patients, "off" episodes improved (from daily mean of 273 minutes, to 172 minutes). In summary, memantine addition to parkinsonian features, could form a basis for novel therapeutic strategies directed to neutralize the effects of glutamate at striatal and subthalamic levels.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalJournal of Neural Transmission - Parkinson's Disease and Dementia Section
Volume4
Issue number4
DOIs
StatePublished - Dec 1992
Externally publishedYes

Keywords

  • Memantine
  • NMDA receptor antagonists
  • Parkinson's disease

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