Efficacy of lithium-tranylcypromine treatment in refractory depression

L. H. Price, D. S. Charney, G. R. Heninger

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Twelve inpatients with major depression refractory to at least two controlled antidepressant trials had tranylcypromine added to ongoing lithium treatment. Eleven patients showed reliable improvement in nurses' depression ratings compared with a prior trial of lithium added to an antidepressant that was not a monoamine oxidase inhibitor (MAOI). Eight patients were blindly judged much or very much improved, and all 12 patients improved sufficiently to be discharged. Preclinical studies of conjointly administered lithium and MAOIs suggest that central serotonergic pathways may mediate this robust clinical effect.

Original languageEnglish
Pages (from-to)619-623
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number5
StatePublished - 1985
Externally publishedYes


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