Efficacy of Cognitive Behavioral Therapy in Heart Failure Patients: A Systematic Review and Meta-Analysis

Nso Nso, Kelechi Emmanuel, Mahmoud Nassar, Kaveh Rezaei Bookani, Daniel Antwi-Amoabeng, Mohsen Alshamam, Ravali Kondaveeti, Ritika Kompella, Sofia Lakhdar, Vincent Rizzo, Miry Sorkin, Most Sirajum Munira, Farshid Radparvar

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Background: Heart failure (HF) is a global disorder affecting around 6.2 million Americans aged 20 years and above. Neurovegetative disorders are common among such patients, and depression is a major problem that affects 20% to 40% of them. Cognitive behavioral therapy (CBT) is a type of treatment that produces the most favorable results compared to other psychotherapies, especially among patients with depression and anxiety. We aim to summarize and synthesize evidence regarding the efficacy of CBT for patients with HF. Methods: We conducted this study by searching PubMed, Scopus, and Web of Science for relevant studies about CBT use in patients with HF. The outcomes were pooled as mean difference (MD) or standard MD with a 95% CI. The analysis was performed using the RevMan software. Results: Combined data from 9 randomized controlled trials (1070 patients) revealed that CBT can alleviate both depression symptoms in HF patients when measured using different scales after 3 months of follow-up (standard MD, -0.18 [95% CI, -0.33 to -0.02]; P = 0.03) and the quality of life after 3 and 6 months of follow-up (MD, 4.92 [95% CI, 1.14-8.71]; P = 0.01 and MD, 7.72 [95% CI, 0.77-14.68]; P = 0.03, respectively). Conclusion: CBT is an effective type of psychotherapy for dealing with depression, mediocre quality of life, and defective physical functioning; therefore, it should be considered in HF patients' care.

Original languageEnglish
Pages (from-to)139-148
Number of pages10
JournalCardiology in Review
Issue number3
StatePublished - 1 May 2023


  • cardiovascular disease
  • cognitive behavioral therapy
  • heart failure
  • psychological intervention
  • psychotherapy


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