Efficacy of anthiyperglycemic therapies and the influence of baseline hemoglobin A1C: A meta-analysis of the liraglutide development program

Robert Henry, John Buse, Giorgio Sesti, Melanie Davies, Klaus Jensen, Jason Brett, Richard Pratley

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Objective: To compare liraglutide versus common antihyperglycemic treatments in reducing hemoglobin A1c (A1C) values across multiple levels of baseline glycemic control and in reaching glycemic targets. Methods: Pooled patient data from 7 phase 3, multinational, randomized controlled trials in patients with type 2 diabetes were stratified by baseline A1c values into 5 categories: 7.5%, >7.5% to 8.0%, >8.0% to 8.5%, >8.5% to 9.0%, and y9.0%. The changes in A1c from baseline to week 26 of treatment and patient proportions reaching A1c targets of <7.0% and 6.5% were compared between liraglutide (1.8 mg daily) and sitagliptin, glimepiride, rosiglit-azone, exenatide, and insulin glargine across all baseline A1c categories.Results: Irrespective of treatment, reductions in A1c levels were generally greater in groups with higher baseline A1c values. After 26 weeks of treatment, liraglutide produced the greatest reductions in A1c values across all baseline categories, ranging from 0.7% to 1.8% (baseline A1c categories 7.5% to >9.0%, respectively), followed by insulin glargine (0.3% to 1.5%) and then by glimepiride (0.4% to 1.3%). Generally, larger percentages of patients achieved the A1c target of 6.5% with liraglutide therapy across all baseline categories (from 62% of patients with A1c values 7.5% to 10% of patients with A1c values >9.0%) in comparison with other treatments (ranging from 49% to 0% of patients, respectively). Similarly, greater proportions of patients also reached the A1c target of <7.0% with liraglutide therapy across all baseline categories (from 83% of patients with A1c values 7.5% to 25% of patients with A1c values >9.0%) versus comparators (from 74% to 5% of patients, respectively). Conclusion: Across a wide spectrum of baseline A1c categories, liraglutide is an efficacious treatment option for patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)906-913
Number of pages8
JournalEndocrine Practice
Volume17
Issue number6
DOIs
StatePublished - 1 Nov 2011
Externally publishedYes

Fingerprint

Dive into the research topics of 'Efficacy of anthiyperglycemic therapies and the influence of baseline hemoglobin A1C: A meta-analysis of the liraglutide development program'. Together they form a unique fingerprint.

Cite this