Efficacy and tolerability of fesoterodine in women with overactive bladder

Peter K. Sand, Jon D. Morrow, Tamara Bavendam, Dana L. Creanga, Victor W. Nitti

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Introduction and hypothesis: We assessed fesoterodine efficacy and tolerability in women with overactive bladder (OAB). Methods: This posthoc analysis of pooled data from two clinical trials included 1,548 women with OAB randomized to placebo, fesoterodine 4 or 8 mg, or tolterodine extended release (ER) 4 mg (in 1 trial) for 12 weeks. Subjects completed 3-day bladder diaries at baseline and weeks 2 and 12 and rated Treatment Response at weeks 2 and 12. Results: By weeks 2 and 12, all active-treatment groups showed significant improvements in all five bladder diary variables assessed and greater Treatment Response rates vs placebo. Fesoterodine 8 mg was significantly more efficacious than fesoterodine 4 mg and tolterodine ER in improving urgency urinary incontinence episodes and continent days per week. The most common adverse events were dry mouth and constipation, which were predominately mild or moderate. Conclusions: Fesoterodine is efficacious and well tolerated in women with OAB.

Original languageEnglish
Pages (from-to)827-835
Number of pages9
JournalInternational Urogynecology Journal
Volume20
Issue number7
DOIs
StatePublished - Jul 2009
Externally publishedYes

Keywords

  • Antimuscarinic
  • Dose response
  • Incontinence
  • Overactive bladder
  • Treatment response

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