Efficacy and Tolerability of a Procedure Enhancement System with TriHex Technology®as a Pre- and Post-Radiofrequency Microneedling Regimen

Jennifer A. Croix, Shannon Hernandez, Jennifer Chwalek, Robyn Gmyrek, Anne Chapas

Research output: Contribution to journalArticlepeer-review

Abstract

Postoperative recovery is an important consideration for patients planning dermal rejuvenation procedures. A topical procedure enhancement system (PES) containing a tripeptide and hexapeptide (TriHex Technology®; Alastin Skincare®, Carlsbad, CA) hastens recovery from facial rejuvenation procedures, such as laser resurfacing. We assessed the efficacy and tolerability of the PES compared to a standard-of-care antioxidant regimen for improving recovery following three monthly facial radiofrequency (RF) microneedling treatments. Assessments included grading pre- and posttreatment digital images by two blinded physicians and a subject satisfaction questionnaire. Digital images revealed significantly less post-RF erythema following the introduction of the PES in a crossover study. Similarly, the side treated with the PES in a split-face study demonstrated significantly less post-RF erythema than the antioxidant regimen. Participants expressed preference for the PES. Expected adverse effects included immediate, posttreatment erythema, edema, and burning/stinging. Other adverse effects included acneiform eruptions in patients treated with the antioxidant regimen (n = 2) and the PES regimen (n = 1) and mild dermatitis in another PES-treated patient. A topical PES containing a tripeptide and hexapeptide appears to be a safer and effective regimen for reducing posttreatment erythema and accelerates recovery following RF microneedling.

Original languageEnglish
Pages (from-to)426-431
Number of pages6
JournalSkinmed
Volume19
Issue number6
StatePublished - 2021
Externally publishedYes

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