Effetti patologici causati da chemioterapici antiblastici nei lavoratori addetti alla loro produzione, preparazione o somministrazione

Translated title of the contribution: Adverse effects of exposure in production, handling and administration of antineoplastic drugs

E. Merler, L. Villa, R. Lucchini

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

This article reviews the adverse effects of exposure to antineoplastic drugs in workers producing or administering them. Many antineoplastic drugs are carcinogenic or mutagenic to humans and exposure and absorption have been shown to occur during production in pharmaceutical industries or during the preparation and administration in veterinary and health practice. At present few studies have been made on the increased risk of cancer for workers handling these chemicals. However, available data suggest an increased risk of cancer due to exposure to antineoplastic drugs and increased risk of spontaneous abortions and offspring malformations among women workers. This poses a major problem since the majority of health care workers exposed to antineoplastic drugs are women. Therefore, because of these reported effects, it is of the utmost importance to avoid any contact with, and any absorption of these chemicals by using adequate protective equipment during their preparation and administration and by organizing preventive educational programs for the workers.

Translated title of the contributionAdverse effects of exposure in production, handling and administration of antineoplastic drugs
Original languageUndefined/Unknown
Pages (from-to)207-221
Number of pages15
JournalMedicina del Lavoro
Volume87
Issue number3
StatePublished - 1996
Externally publishedYes

Keywords

  • antineoplastic drugs
  • carcinogenic effects
  • occupational exposure
  • teratogenic effects

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