Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type

Brien Smith; Rhonna Shatz; Kost Elisevich; Irina N. Bespalova; Margit Burmeister

doi:10.1111/j.1528-1157.2000.tb00293.x

Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type

Brien Smith, Rhonna Shatz, Kost Elisevich, Irina N. Bespalova, Margit Burmeister

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Purpose: A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy. Methods: After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed. Results: VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living. Conclusions: VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.

Original language	English
Pages (from-to)	1046-1048
Number of pages	3
Journal	Epilepsia
Volume	41
Issue number	8
DOIs	https://doi.org/10.1111/j.1528-1157.2000.tb00293.x
State	Published - 2000
Externally published	Yes

Keywords

Electrical stimulation
Epilepsy
Progressive myoclonus epilepsy
Seizure
Vagus nerve

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10.1111/j.1528-1157.2000.tb00293.x

Cite this

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title = "Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type",

abstract = "Purpose: A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy. Methods: After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed. Results: VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living. Conclusions: VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.",

keywords = "Electrical stimulation, Epilepsy, Progressive myoclonus epilepsy, Seizure, Vagus nerve",

author = "Brien Smith and Rhonna Shatz and Kost Elisevich and Bespalova, {Irina N.} and Margit Burmeister",

year = "2000",

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journal = "Epilepsia",

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AU - Shatz, Rhonna

AU - Elisevich, Kost

AU - Bespalova, Irina N.

AU - Burmeister, Margit

PY - 2000

Y1 - 2000

N2 - Purpose: A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy. Methods: After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed. Results: VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living. Conclusions: VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.

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Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type

Abstract

Keywords

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