Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

Lawrence H. Price; Dennis S. Charney; George R. Heninger

doi:10.1007/BF00175186

Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

Lawrence H. Price, Dennis S. Charney, George R. Heninger

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20 Scopus citations

Abstract

Tricyclic antidepressant drugs reduce the sensitivity of α₂ adrenoceptors during long-term treatment. In the present study, the α₂ adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic α₂ receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in α₂ adrenoceptor sensitivity.

Original language	English
Pages (from-to)	38-44
Number of pages	7
Journal	Psychopharmacology
Volume	89
Issue number	1
DOIs	https://doi.org/10.1007/BF00175186
State	Published - May 1986
Externally published	Yes

Keywords

Antidepressants
Clonidine
Growth hormone
MHPG
Trazodone
α Adrenoceptors

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10.1007/BF00175186

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title = "Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients",

abstract = "Tricyclic antidepressant drugs reduce the sensitivity of α2 adrenoceptors during long-term treatment. In the present study, the α2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic α2 receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in α2 adrenoceptor sensitivity.",

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AU - Price, Lawrence H.

AU - Charney, Dennis S.

AU - Heninger, George R.

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N2 - Tricyclic antidepressant drugs reduce the sensitivity of α2 adrenoceptors during long-term treatment. In the present study, the α2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic α2 receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in α2 adrenoceptor sensitivity.

AB - Tricyclic antidepressant drugs reduce the sensitivity of α2 adrenoceptors during long-term treatment. In the present study, the α2 adrenergic agonist clonidine was administered to 11 depressed patients before and during treatment with the triazolopyridine antidepressant trazodone (TRZ). Clonidine's ability to decrease blood pressure (BP) and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG), and to increase sedation and plasma growth hormone (GH), were measured. TRZ had little effect on these indices of pre- and postsynaptic α2 receptor function, suggesting that the antidepressant properties of TRZ are not related to changes in α2 adrenoceptor sensitivity.

KW - Antidepressants

KW - Clonidine

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KW - MHPG

KW - Trazodone

KW - α Adrenoceptors

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JO - Psychopharmacology

JF - Psychopharmacology

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Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients

Abstract

Keywords

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