Effects of thyrotrophin releasing hormone on prolactin, plasma renin activity, water and electrolyte excretion in normal males

S. Epstein, R. Van Zyl Smit, D. Le Roith

Research output: Contribution to journalArticlepeer-review

Abstract

The injection of ovine prolactin (PRL) in normal man causes retention of water, sodium and potassium. Human prolactin (HPRL) has been implicated in nocturnal antidiuresis and its absence may allow saluresis and the 'escape phenomenon' in endocrine hypertension. The authors studied the effects of thyrotrophinreleasing hormone (TRH) stimulated PRL release on electrolyte, water and plasma renin activity (PRA) in normal male volunteers to clarify the role of HPRL in electrolyte and water excretion. Seven subjects who were given 200 μg TRH with stimulation of prolactin (HPRL) had no alteration in urinary sodium, potassium and free water clearance. In addition, PRA remained unaffected by the elevation in HPRL. They conclude that acute elevation of HPRL does not alter water and electrolyte and PRA homeostasis in normal man, or else counterregulatory mechanisms by unknown concomitant effects of TRH or TSH might be operative.

Original languageEnglish
Pages (from-to)996
Number of pages1
JournalSouth African Medical Journal
Volume50
Issue number26
StatePublished - 1976
Externally publishedYes

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