Effects of sho-saiko-to on production of prostaglandin e2 (PGE2), leukotriene B4 (LTB4) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals

Koji Miyamoto; Michael Lange; George McKinley; Christine Stavropoulos; Shin Ichi Moriya; Hirotaka Matsumoto; Yoritaro Inada

doi:10.1142/S0192415X96000025

Effects of sho-saiko-to on production of prostaglandin e₂ (PGE₂), leukotriene B₄ (LTB₄) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals

Koji Miyamoto, Michael Lange, George McKinley, Christine Stavropoulos, Shin Ichi Moriya, Hirotaka Matsumoto, Yoritaro Inada

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of Sho-saiko-to (SST), a traditional Chinese medicine, on the production of PGE₂ from monocytes, LTB₄ and Superoxide from polymorphonuclear cells (PMNC) in HIV infected individuals were studied. SST inhibited the production of PGE₂ from monocytes stimulated by opsonized zymosan in all groups including the healthy control group and also inhibited the production of superoxide from PMNC after stimulation with FMLP. On the other hand, SST enhanced the production of LTB₄ when PMNC were stimulated by the calcium ionophore A23187. These results suggest that SST has different effects on the production of prostanoids or superoxide from monocytes and PMNC. Furthermore, our data indicates that inhibition of PGE₂ or superoxide production will lead to indirect suppression of HIV, and enhancement of LTB4 will contribute to the upregulation of the immune reaction in HIV infected individuals.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	American Journal of Chinese Medicine
Volume	24
Issue number	1
DOIs	https://doi.org/10.1142/S0192415X96000025
State	Published - 1996
Externally published	Yes

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Miyamoto, K., Lange, M., McKinley, G., Stavropoulos, C., Moriya, S. I., Matsumoto, H., & Inada, Y. (1996). Effects of sho-saiko-to on production of prostaglandin e₂ (PGE₂), leukotriene B₄ (LTB₄) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals. American Journal of Chinese Medicine, 24(1), 1-10. https://doi.org/10.1142/S0192415X96000025

@article{a58af15ef5a445a790cb4c670f85529e,

title = "Effects of sho-saiko-to on production of prostaglandin e2 (PGE2), leukotriene B4 (LTB4) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals",

abstract = "The effects of Sho-saiko-to (SST), a traditional Chinese medicine, on the production of PGE2 from monocytes, LTB4 and Superoxide from polymorphonuclear cells (PMNC) in HIV infected individuals were studied. SST inhibited the production of PGE2 from monocytes stimulated by opsonized zymosan in all groups including the healthy control group and also inhibited the production of superoxide from PMNC after stimulation with FMLP. On the other hand, SST enhanced the production of LTB4 when PMNC were stimulated by the calcium ionophore A23187. These results suggest that SST has different effects on the production of prostanoids or superoxide from monocytes and PMNC. Furthermore, our data indicates that inhibition of PGE2 or superoxide production will lead to indirect suppression of HIV, and enhancement of LTB4 will contribute to the upregulation of the immune reaction in HIV infected individuals.",

author = "Koji Miyamoto and Michael Lange and George McKinley and Christine Stavropoulos and Moriya, {Shin Ichi} and Hirotaka Matsumoto and Yoritaro Inada",

year = "1996",

doi = "10.1142/S0192415X96000025",

language = "English",

volume = "24",

pages = "1--10",

journal = "American Journal of Chinese Medicine",

issn = "0192-415X",

publisher = "World Scientific",

number = "1",

}

Miyamoto, K, Lange, M, McKinley, G, Stavropoulos, C, Moriya, SI, Matsumoto, H & Inada, Y 1996, 'Effects of sho-saiko-to on production of prostaglandin e₂ (PGE₂), leukotriene B₄ (LTB₄) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals', American Journal of Chinese Medicine, vol. 24, no. 1, pp. 1-10. https://doi.org/10.1142/S0192415X96000025

Effects of sho-saiko-to on production of prostaglandin e₂ (PGE₂), leukotriene B₄ (LTB₄) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals. / Miyamoto, Koji; Lange, Michael; McKinley, George et al.
In: American Journal of Chinese Medicine, Vol. 24, No. 1, 1996, p. 1-10.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of sho-saiko-to on production of prostaglandin e2 (PGE2), leukotriene B4 (LTB4) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals

AU - Miyamoto, Koji

AU - Lange, Michael

AU - McKinley, George

AU - Stavropoulos, Christine

AU - Moriya, Shin Ichi

AU - Matsumoto, Hirotaka

AU - Inada, Yoritaro

PY - 1996

Y1 - 1996

N2 - The effects of Sho-saiko-to (SST), a traditional Chinese medicine, on the production of PGE2 from monocytes, LTB4 and Superoxide from polymorphonuclear cells (PMNC) in HIV infected individuals were studied. SST inhibited the production of PGE2 from monocytes stimulated by opsonized zymosan in all groups including the healthy control group and also inhibited the production of superoxide from PMNC after stimulation with FMLP. On the other hand, SST enhanced the production of LTB4 when PMNC were stimulated by the calcium ionophore A23187. These results suggest that SST has different effects on the production of prostanoids or superoxide from monocytes and PMNC. Furthermore, our data indicates that inhibition of PGE2 or superoxide production will lead to indirect suppression of HIV, and enhancement of LTB4 will contribute to the upregulation of the immune reaction in HIV infected individuals.

AB - The effects of Sho-saiko-to (SST), a traditional Chinese medicine, on the production of PGE2 from monocytes, LTB4 and Superoxide from polymorphonuclear cells (PMNC) in HIV infected individuals were studied. SST inhibited the production of PGE2 from monocytes stimulated by opsonized zymosan in all groups including the healthy control group and also inhibited the production of superoxide from PMNC after stimulation with FMLP. On the other hand, SST enhanced the production of LTB4 when PMNC were stimulated by the calcium ionophore A23187. These results suggest that SST has different effects on the production of prostanoids or superoxide from monocytes and PMNC. Furthermore, our data indicates that inhibition of PGE2 or superoxide production will lead to indirect suppression of HIV, and enhancement of LTB4 will contribute to the upregulation of the immune reaction in HIV infected individuals.

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Effects of sho-saiko-to on production of prostaglandin e2 (PGE2), leukotriene B4 (LTB4) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals

Abstract

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Effects of sho-saiko-to on production of prostaglandin e₂ (PGE₂), leukotriene B₄ (LTB₄) and superoxide from peripheral monocytes and polymorphonuclear cells isolated from HIV infected individuals