Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects

John P. Seibyl; John H. Krystal; Lawrence H. Price; Scott W. Woods; Cynthia D'Amico; George R. Heninger; Dennis S. Charney

doi:10.1016/0165-1781(91)90013-F

Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects

John P. Seibyl, John H. Krystal, Lawrence H. Price, Scott W. Woods, Cynthia D'Amico, George R. Heninger, Dennis S. Charney

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Ten healthy male subjects were administered i.v. meta-chlorophenyl-piperazine (MCPP) (0.1 mg/kg) after oral ritanserin (5-10 mg), a putative 5HT_1c/5HT₂ (serotonin) antagonist, or placebo. Behavioral responses, cardiovascular effects, and neuroendocrine responses (cortisol, growth hormone, and prolactin) were measured serially for 4 hours after MCPP infusion. Premedication with ritanserin attenuated the MCPP-induced increases in self-rated anxiety and prolactin, and completely antagonized MCPP cortisol elevations. In contrast, ritanserin did not significantly alter growth hormone response to MCPP. These findings suggest a role for 5-HT_1c/5-HT₂ receptors in the endocrine and behavioral responses to the mixed serotonin agonist MCPP in humans.

Original language	English
Pages (from-to)	227-236
Number of pages	10
Journal	Psychiatry Research
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(91)90013-F
State	Published - Sep 1991
Externally published	Yes

Keywords

Ritanserin
anxiety
meta-chlorophenylpiperazine
serotonin

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10.1016/0165-1781(91)90013-F

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@article{057402cc5d004e2bbd754d028f5508f8,

title = "Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects",

abstract = "Ten healthy male subjects were administered i.v. meta-chlorophenyl-piperazine (MCPP) (0.1 mg/kg) after oral ritanserin (5-10 mg), a putative 5HT1c/5HT2 (serotonin) antagonist, or placebo. Behavioral responses, cardiovascular effects, and neuroendocrine responses (cortisol, growth hormone, and prolactin) were measured serially for 4 hours after MCPP infusion. Premedication with ritanserin attenuated the MCPP-induced increases in self-rated anxiety and prolactin, and completely antagonized MCPP cortisol elevations. In contrast, ritanserin did not significantly alter growth hormone response to MCPP. These findings suggest a role for 5-HT1c/5-HT2 receptors in the endocrine and behavioral responses to the mixed serotonin agonist MCPP in humans.",

keywords = "Ritanserin, anxiety, meta-chlorophenylpiperazine, serotonin",

author = "Seibyl, {John P.} and Krystal, {John H.} and Price, {Lawrence H.} and Woods, {Scott W.} and Cynthia D'Amico and Heninger, {George R.} and Charney, {Dennis S.}",

note = "Funding Information: Acknowledgments. Supportf or this work was provided by the Department of Veterans{\textquoteright} Affairs Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder, the Schizophrenia Biological Research Center, and Department of Veterans{\textquoteright} Affairs grant to Dr. Charney. The authors are grateful to the Janssen Research Foundation for providing ritanserin.",

year = "1991",

month = sep,

doi = "10.1016/0165-1781(91)90013-F",

language = "English",

volume = "38",

pages = "227--236",

journal = "Psychiatry Research",

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publisher = "Elsevier Ireland Ltd",

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T1 - Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects

AU - Seibyl, John P.

AU - Krystal, John H.

AU - Price, Lawrence H.

AU - Woods, Scott W.

AU - D'Amico, Cynthia

AU - Heninger, George R.

AU - Charney, Dennis S.

N1 - Funding Information: Acknowledgments. Supportf or this work was provided by the Department of Veterans’ Affairs Clinical Neurosciences Division of the National Center for Posttraumatic Stress Disorder, the Schizophrenia Biological Research Center, and Department of Veterans’ Affairs grant to Dr. Charney. The authors are grateful to the Janssen Research Foundation for providing ritanserin.

PY - 1991/9

Y1 - 1991/9

N2 - Ten healthy male subjects were administered i.v. meta-chlorophenyl-piperazine (MCPP) (0.1 mg/kg) after oral ritanserin (5-10 mg), a putative 5HT1c/5HT2 (serotonin) antagonist, or placebo. Behavioral responses, cardiovascular effects, and neuroendocrine responses (cortisol, growth hormone, and prolactin) were measured serially for 4 hours after MCPP infusion. Premedication with ritanserin attenuated the MCPP-induced increases in self-rated anxiety and prolactin, and completely antagonized MCPP cortisol elevations. In contrast, ritanserin did not significantly alter growth hormone response to MCPP. These findings suggest a role for 5-HT1c/5-HT2 receptors in the endocrine and behavioral responses to the mixed serotonin agonist MCPP in humans.

AB - Ten healthy male subjects were administered i.v. meta-chlorophenyl-piperazine (MCPP) (0.1 mg/kg) after oral ritanserin (5-10 mg), a putative 5HT1c/5HT2 (serotonin) antagonist, or placebo. Behavioral responses, cardiovascular effects, and neuroendocrine responses (cortisol, growth hormone, and prolactin) were measured serially for 4 hours after MCPP infusion. Premedication with ritanserin attenuated the MCPP-induced increases in self-rated anxiety and prolactin, and completely antagonized MCPP cortisol elevations. In contrast, ritanserin did not significantly alter growth hormone response to MCPP. These findings suggest a role for 5-HT1c/5-HT2 receptors in the endocrine and behavioral responses to the mixed serotonin agonist MCPP in humans.

KW - Ritanserin

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ER -

Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects

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Keywords

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