Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation

Marta Martín-Fernández; Elena Martínez; Manuel Díaz-Curiel; David Guede; José Ramón Caeiro; Concepción De La Piedra

doi:10.3109/13685538.2013.821697

Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation

Marta Martín-Fernández
, Elena Martínez
, Manuel Díaz-Curiel
, David Guede
, José Ramón Caeiro
, Concepción De La Piedra

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aim: The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) (1-84) in a model of male osteoporosis induced by orchidectomy in rats. Methods: Six-month-old Wistar rats were used as follows: SHAM (simulated orchidectomy), orchidectomized (ORX), ORX+PTH1 (ORX and treated with 10g/Kg/d of PTH 1-84) and ORX+PTH2 (ORX and treated with 50g/Kg/d of PTH 1-84) over 3 months, with treatment beginning three months after orchidectomy. Results: Orchidectomy resulted in a decreased of femoral and lumbar bone mineral density (BMD), a worsening of trabecular and cortical microarchitecture and a decrease in biomechanical properties. Both doses of PTH (1-84) partially (low dose) or totally (high dose) restored the ORX-induced changes. Serum C-telopeptide of type I collagen/5b isoenzyme of tartrate-resistant acid phosphatase (CTX/TRAP) resorption index increased after orchidectomy. Osteocalcin (bone Gla protein; BGP) levels were not affected by orchidectomy. PTH (1-84) treatment did not produce any changes in the levels of CTX/TRAP with respect to the ORX group. BGP levels increased with PTH treatment. Conclusion: PTH (1-84) is able to restore the adverse effects of orchidectomy on bone as measured by BMD, microstructural and biomechanical properties and bone remodeling markers.

Original language	English
Pages (from-to)	42-50
Number of pages	9
Journal	Aging Male
Volume	17
Issue number	1
DOIs	https://doi.org/10.3109/13685538.2013.821697
State	Published - Mar 2014
Externally published	Yes

Keywords

Male osteoporosis
Male rat
Orchidectomy
PTH (1-84)

Access to Document

10.3109/13685538.2013.821697

Cite this

@article{88bd93db70c042ea8af965427e731148,

title = "Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation",

abstract = "Aim: The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) (1-84) in a model of male osteoporosis induced by orchidectomy in rats. Methods: Six-month-old Wistar rats were used as follows: SHAM (simulated orchidectomy), orchidectomized (ORX), ORX+PTH1 (ORX and treated with 10g/Kg/d of PTH 1-84) and ORX+PTH2 (ORX and treated with 50g/Kg/d of PTH 1-84) over 3 months, with treatment beginning three months after orchidectomy. Results: Orchidectomy resulted in a decreased of femoral and lumbar bone mineral density (BMD), a worsening of trabecular and cortical microarchitecture and a decrease in biomechanical properties. Both doses of PTH (1-84) partially (low dose) or totally (high dose) restored the ORX-induced changes. Serum C-telopeptide of type I collagen/5b isoenzyme of tartrate-resistant acid phosphatase (CTX/TRAP) resorption index increased after orchidectomy. Osteocalcin (bone Gla protein; BGP) levels were not affected by orchidectomy. PTH (1-84) treatment did not produce any changes in the levels of CTX/TRAP with respect to the ORX group. BGP levels increased with PTH treatment. Conclusion: PTH (1-84) is able to restore the adverse effects of orchidectomy on bone as measured by BMD, microstructural and biomechanical properties and bone remodeling markers.",

keywords = "Male osteoporosis, Male rat, Orchidectomy, PTH (1-84)",

author = "Marta Mart{\'i}n-Fern{\'a}ndez and Elena Mart{\'i}nez and Manuel D{\'i}az-Curiel and David Guede and Caeiro, \{Jos{\'e} Ram{\'o}n\} and \{De La Piedra\}, Concepci{\'o}n",

note = "Funding Information: This work was supported by a grant from Nycomed Pharma (Spain). Marta Mart{\'i}n-Fern{\'a}ndez was a fellow of the Conchita R{\'a}bago Foundation.",

year = "2014",

month = mar,

doi = "10.3109/13685538.2013.821697",

language = "English",

volume = "17",

pages = "42--50",

journal = "Aging Male",

issn = "1368-5538",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation

AU - Martín-Fernández, Marta

AU - Martínez, Elena

AU - Díaz-Curiel, Manuel

AU - Guede, David

AU - Caeiro, José Ramón

AU - De La Piedra, Concepción

N1 - Funding Information: This work was supported by a grant from Nycomed Pharma (Spain). Marta Martín-Fernández was a fellow of the Conchita Rábago Foundation.

PY - 2014/3

Y1 - 2014/3

N2 - Aim: The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) (1-84) in a model of male osteoporosis induced by orchidectomy in rats. Methods: Six-month-old Wistar rats were used as follows: SHAM (simulated orchidectomy), orchidectomized (ORX), ORX+PTH1 (ORX and treated with 10g/Kg/d of PTH 1-84) and ORX+PTH2 (ORX and treated with 50g/Kg/d of PTH 1-84) over 3 months, with treatment beginning three months after orchidectomy. Results: Orchidectomy resulted in a decreased of femoral and lumbar bone mineral density (BMD), a worsening of trabecular and cortical microarchitecture and a decrease in biomechanical properties. Both doses of PTH (1-84) partially (low dose) or totally (high dose) restored the ORX-induced changes. Serum C-telopeptide of type I collagen/5b isoenzyme of tartrate-resistant acid phosphatase (CTX/TRAP) resorption index increased after orchidectomy. Osteocalcin (bone Gla protein; BGP) levels were not affected by orchidectomy. PTH (1-84) treatment did not produce any changes in the levels of CTX/TRAP with respect to the ORX group. BGP levels increased with PTH treatment. Conclusion: PTH (1-84) is able to restore the adverse effects of orchidectomy on bone as measured by BMD, microstructural and biomechanical properties and bone remodeling markers.

AB - Aim: The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) (1-84) in a model of male osteoporosis induced by orchidectomy in rats. Methods: Six-month-old Wistar rats were used as follows: SHAM (simulated orchidectomy), orchidectomized (ORX), ORX+PTH1 (ORX and treated with 10g/Kg/d of PTH 1-84) and ORX+PTH2 (ORX and treated with 50g/Kg/d of PTH 1-84) over 3 months, with treatment beginning three months after orchidectomy. Results: Orchidectomy resulted in a decreased of femoral and lumbar bone mineral density (BMD), a worsening of trabecular and cortical microarchitecture and a decrease in biomechanical properties. Both doses of PTH (1-84) partially (low dose) or totally (high dose) restored the ORX-induced changes. Serum C-telopeptide of type I collagen/5b isoenzyme of tartrate-resistant acid phosphatase (CTX/TRAP) resorption index increased after orchidectomy. Osteocalcin (bone Gla protein; BGP) levels were not affected by orchidectomy. PTH (1-84) treatment did not produce any changes in the levels of CTX/TRAP with respect to the ORX group. BGP levels increased with PTH treatment. Conclusion: PTH (1-84) is able to restore the adverse effects of orchidectomy on bone as measured by BMD, microstructural and biomechanical properties and bone remodeling markers.

KW - Male osteoporosis

KW - Male rat

KW - Orchidectomy

KW - PTH (1-84)

UR - https://www.scopus.com/pages/publications/84896738736

U2 - 10.3109/13685538.2013.821697

DO - 10.3109/13685538.2013.821697

M3 - Article

C2 - 23914846

AN - SCOPUS:84896738736

SN - 1368-5538

VL - 17

SP - 42

EP - 50

JO - Aging Male

JF - Aging Male

IS - 1

ER -

Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation

Abstract

Keywords

Access to Document

Fingerprint

Cite this