Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation

John J. Bruno; Leslie A. Taylor; Michael J. Droller

doi:10.1038/251721a0

Effects of prostaglandin E₂ on human platelet adenyl cyclase and aggregation

John J. Bruno
, Leslie A. Taylor
, Michael J. Droller

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

THE ability of prostaglandins to affect platelet function has been described in many laboratories^1,2. The most potent of these, prostaglandin E₁ (PGE₁), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E₂ (PGE₂), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined³ and the concentration of prostaglandin used⁴.

Original language	English
Pages (from-to)	721-723
Number of pages	3
Journal	Nature
Volume	251
Issue number	5477
DOIs	https://doi.org/10.1038/251721a0
State	Published - 1974
Externally published	Yes

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@article{2e93899e88524e4a9fa24927159b8ee8,

title = "Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation",

abstract = "THE ability of prostaglandins to affect platelet function has been described in many laboratories1,2. The most potent of these, prostaglandin E1 (PGE1), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E2 (PGE2), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined3 and the concentration of prostaglandin used4.",

author = "Bruno, \{John J.\} and Taylor, \{Leslie A.\} and Droller, \{Michael J.\}",

year = "1974",

doi = "10.1038/251721a0",

language = "English",

volume = "251",

pages = "721--723",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "5477",

}

TY - JOUR

T1 - Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation

AU - Bruno, John J.

AU - Taylor, Leslie A.

AU - Droller, Michael J.

PY - 1974

Y1 - 1974

N2 - THE ability of prostaglandins to affect platelet function has been described in many laboratories1,2. The most potent of these, prostaglandin E1 (PGE1), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E2 (PGE2), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined3 and the concentration of prostaglandin used4.

AB - THE ability of prostaglandins to affect platelet function has been described in many laboratories1,2. The most potent of these, prostaglandin E1 (PGE1), has been found to inhibit platelet aggregation and stimulate platelet adenyl cyclase. The effect of prostaglandin E2 (PGE2), however, has been either inhibitory or stimulatory, depending both upon the species of animal examined3 and the concentration of prostaglandin used4.

UR - https://www.scopus.com/pages/publications/0016313921

U2 - 10.1038/251721a0

DO - 10.1038/251721a0

M3 - Article

C2 - 4427671

AN - SCOPUS:0016313921

SN - 0028-0836

VL - 251

SP - 721

EP - 723

JO - Nature

JF - Nature

IS - 5477

ER -

Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation

Abstract

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Effects of prostaglandin E₂ on human platelet adenyl cyclase and aggregation