Effects of portal vein arterialization on liver regeneration in hepatocirrhosis after partial hepatectomy in dogs

Peng Wang, Peng Li, Li Rui, Hou Xiang Li, Hai Xin Qian

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To study the effects of portal vein arterialization (PVA) on the liver regeneration in hepatocirrhosis after partial hepatectomy in dogs in order to provide a basis for its clinical use. METHODS: The liver cirrhosis model of dogs was established. The dogs were divided into three groups randomly: group A (PVA group), partial hepatectomy plus PVA; group B (control group), partial hepatectomy; and group C, sham-operated group. All dogs were killed four weeks after operation. During the experiment, liver regeneration rate, expression of proliferating cell nuclear antigen (PCNA) in liver tissue and arterial ketone body ratio(AKBR) were observed. RESULTS: Liver regeneration rate was significantly higher in group A than in group B (86.6% ± 2.9% vs 73.7% ± 6.9%, P < 0.01); the AKBR of groups A and B was significantly lower than group C (both P < 0.01), but 4 wks after operation , the AKBR of group A(1.32 ± 0.14) became close to group C (1.33 ± 0.11), without significant difference (P > 0.05); the expression of PCNA in liver tissues of group A was significantly faster than group B. CONCLUSION: PVA has significantly positive effect on liver regeneration after partial hepatectomy in dogs with hepatocirrhosis.

Original languageEnglish
Pages (from-to)2499-2502
Number of pages4
JournalWorld Chinese Journal of Digestology
Volume17
Issue number24
DOIs
StatePublished - 28 Aug 2009
Externally publishedYes

Keywords

  • Hepatocirrhosis
  • Liver regeneration
  • Portal vein arterialization

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