Effects of picrotoxin and bicuculline on the excitation and inhibition of Renshaw cells

M. F. Piercey; J. Goldfarb; R. W. Ryall

doi:10.1016/0028-3908(73)90029-4

Effects of picrotoxin and bicuculline on the excitation and inhibition of Renshaw cells

M. F. Piercey
, J. Goldfarb
, R. W. Ryall

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Picrotoxin, a γ-aminobutyric acid (GABA) antagonist, injected intravenously depressed the mutual inhibition of Renshaw cells but this effect was accompanied by a reduction in the excitation of Renshaw cells by motoneurone recurrent collaterals. Bicuculline, another GABA antagonist, did not modify either the excitation or mutai inhibition of Renshaw cells. It is considered unlikely that Renshaw cells contain a pool of GABA that can be released by nerve impulses.

Original language	English
Pages (from-to)	975-982
Number of pages	8
Journal	Neuropharmacology
Volume	12
Issue number	10
DOIs	https://doi.org/10.1016/0028-3908(73)90029-4
State	Published - Oct 1973
Externally published	Yes

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10.1016/0028-3908(73)90029-4

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title = "Effects of picrotoxin and bicuculline on the excitation and inhibition of Renshaw cells",

abstract = "Picrotoxin, a γ-aminobutyric acid (GABA) antagonist, injected intravenously depressed the mutual inhibition of Renshaw cells but this effect was accompanied by a reduction in the excitation of Renshaw cells by motoneurone recurrent collaterals. Bicuculline, another GABA antagonist, did not modify either the excitation or mutai inhibition of Renshaw cells. It is considered unlikely that Renshaw cells contain a pool of GABA that can be released by nerve impulses.",

author = "Piercey, \{M. F.\} and J. Goldfarb and Ryall, \{R. W.\}",

note = "Funding Information: *This investigation was supported in part by grant number ROI-NB-08126 from the National Institute of Neurological Diseases and Stroke and by grant number 688-A-l from the National Multiple Sclerosis Society. M. Piercey was supported by NIH Training arant number 5-TOI-GM 0065. TPresent address: Departmeni of Physiology, Albert Einstein College of Medicine, Bronx, N.Y. 10461. \$Present address: Department of Pharmacology, Mt. Sinai School of Medicine, New York, N.Y. 10029. §Present address: Department of Pharmacology, University of Cambridge.",

year = "1973",

month = oct,

doi = "10.1016/0028-3908(73)90029-4",

language = "English",

volume = "12",

pages = "975--982",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Ltd.",

number = "10",

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T1 - Effects of picrotoxin and bicuculline on the excitation and inhibition of Renshaw cells

AU - Piercey, M. F.

AU - Goldfarb, J.

AU - Ryall, R. W.

N1 - Funding Information: *This investigation was supported in part by grant number ROI-NB-08126 from the National Institute of Neurological Diseases and Stroke and by grant number 688-A-l from the National Multiple Sclerosis Society. M. Piercey was supported by NIH Training arant number 5-TOI-GM 0065. TPresent address: Departmeni of Physiology, Albert Einstein College of Medicine, Bronx, N.Y. 10461. $Present address: Department of Pharmacology, Mt. Sinai School of Medicine, New York, N.Y. 10029. §Present address: Department of Pharmacology, University of Cambridge.

PY - 1973/10

Y1 - 1973/10

N2 - Picrotoxin, a γ-aminobutyric acid (GABA) antagonist, injected intravenously depressed the mutual inhibition of Renshaw cells but this effect was accompanied by a reduction in the excitation of Renshaw cells by motoneurone recurrent collaterals. Bicuculline, another GABA antagonist, did not modify either the excitation or mutai inhibition of Renshaw cells. It is considered unlikely that Renshaw cells contain a pool of GABA that can be released by nerve impulses.

AB - Picrotoxin, a γ-aminobutyric acid (GABA) antagonist, injected intravenously depressed the mutual inhibition of Renshaw cells but this effect was accompanied by a reduction in the excitation of Renshaw cells by motoneurone recurrent collaterals. Bicuculline, another GABA antagonist, did not modify either the excitation or mutai inhibition of Renshaw cells. It is considered unlikely that Renshaw cells contain a pool of GABA that can be released by nerve impulses.

UR - https://www.scopus.com/pages/publications/0015861659

U2 - 10.1016/0028-3908(73)90029-4

DO - 10.1016/0028-3908(73)90029-4

M3 - Article

C2 - 4750565

AN - SCOPUS:0015861659

SN - 0028-3908

VL - 12

SP - 975

EP - 982

JO - Neuropharmacology

JF - Neuropharmacology

IS - 10

ER -

Effects of picrotoxin and bicuculline on the excitation and inhibition of Renshaw cells

Abstract

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