Effects of picrotoxin and bicuculline on the excitation and inhibition of Renshaw cells

M. F. Piercey, J. Goldfarb, R. W. Ryall

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Picrotoxin, a γ-aminobutyric acid (GABA) antagonist, injected intravenously depressed the mutual inhibition of Renshaw cells but this effect was accompanied by a reduction in the excitation of Renshaw cells by motoneurone recurrent collaterals. Bicuculline, another GABA antagonist, did not modify either the excitation or mutai inhibition of Renshaw cells. It is considered unlikely that Renshaw cells contain a pool of GABA that can be released by nerve impulses.

Original languageEnglish
Pages (from-to)975-982
Number of pages8
JournalNeuropharmacology
Volume12
Issue number10
DOIs
StatePublished - Oct 1973
Externally publishedYes

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