Effects of phenylpropanolamine on gastric retention in the adult rat

P. J. Wellman; K. Arasteh; J. L. Ruddle; M. D. Strickland

doi:10.1016/0361-9230(86)90169-3

Effects of phenylpropanolamine on gastric retention in the adult rat

P. J. Wellman
, K. Arasteh
, J. L. Ruddle
, M. D. Strickland

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63 and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.

Original language	English
Pages (from-to)	127-128
Number of pages	2
Journal	Brain Research Bulletin
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/0361-9230(86)90169-3
State	Published - Jul 1986
Externally published	Yes

Keywords

Anorexia Phenylpropanolamine Gastric retention

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10.1016/0361-9230(86)90169-3

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title = "Effects of phenylpropanolamine on gastric retention in the adult rat",

abstract = "Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63 and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.",

keywords = "Anorexia Phenylpropanolamine Gastric retention",

author = "Wellman, \{P. J.\} and K. Arasteh and Ruddle, \{J. L.\} and Strickland, \{M. D.\}",

note = "Funding Information: was supported by a grant from the Thompson Medical",

year = "1986",

month = jul,

doi = "10.1016/0361-9230(86)90169-3",

language = "English",

volume = "17",

pages = "127--128",

journal = "Brain Research Bulletin",

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TY - JOUR

T1 - Effects of phenylpropanolamine on gastric retention in the adult rat

AU - Wellman, P. J.

AU - Arasteh, K.

AU - Ruddle, J. L.

AU - Strickland, M. D.

N1 - Funding Information: was supported by a grant from the Thompson Medical

PY - 1986/7

Y1 - 1986/7

N2 - Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63 and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.

AB - Phenylpropanolamine (PPA) induces anorexia and weight loss via an as yet unidentified mechanism. In the present study, we evaluated the inhibitory action of PPA on gastric emptying. Adult female Sprague-Dawley rats consumed a wet-mash test meal and were then treated (IP) with either saline or 5, 10, 20 or 40 mg/kg PPA. Gastric retention (ratio of weight of gastric content to weight of mash consumed) was evaluated immediately after the meal in a group of saline-treated rats or 3 hours after the meal in the drug groups and another saline-treated group. Rats treated with saline exhibited minimal retention (0.21) over a 3 hour period whereas rats treated with 5, 10, 20 or 40 mg/kg dl-PPA exhibited increased gastric retention ratios of 0.29, 0.66, 0.63 and 1.38, respectively. These data demonstrate that PPA has a marked inhibitory action on gastric emptying and suggest that further studies are warranted to evaluate the possible contribution of gastric retention to the anorexic action of PPA.

KW - Anorexia Phenylpropanolamine Gastric retention

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DO - 10.1016/0361-9230(86)90169-3

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AN - SCOPUS:0022519351

SN - 0361-9230

VL - 17

SP - 127

EP - 128

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 1

ER -

Effects of phenylpropanolamine on gastric retention in the adult rat

Abstract

Keywords

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