Effects of Phenobarbital Pretreatment on the Response of Rat Liver to Halothane Administration

R. J. Stenger; E. A. Johnson

doi:10.3181/00379727-140-36666

Effects of Phenobarbital Pretreatment on the Response of Rat Liver to Halothane Administration

R. J. Stenger
, E. A. Johnson

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Administration of halothane ip to rats pretreated with phenobarbital caused hepatic functional impairment in the immediate postanesthetic period. This impairment was manifested by a significant reduction of hepatic microsomal cytochrome P-450 levels and by a significant prolongation of zoxazola-mine induced paralysis times. Both changes were noted in comparison with anesthetic control values. Similar phenobarbital-halothane-treated animals were killed at 24 hr after anesthesia, and their livers were prepared for histologic evaluation. These livers invariably revealed multiple, discrete foci of parenchymal necrosis; many also displayed patchy subcapsular necrosis, as well. Equal amounts of halothane anesthesia produced neither functional impairment nor hepatic necrosis in rats pretreated with saline instead of phenobarbital.

Original language	English
Pages (from-to)	1319-1324
Number of pages	6
Journal	Experimental Biology and Medicine
Volume	140
Issue number	4
DOIs	https://doi.org/10.3181/00379727-140-36666
State	Published - Sep 1972
Externally published	Yes

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title = "Effects of Phenobarbital Pretreatment on the Response of Rat Liver to Halothane Administration",

abstract = "Administration of halothane ip to rats pretreated with phenobarbital caused hepatic functional impairment in the immediate postanesthetic period. This impairment was manifested by a significant reduction of hepatic microsomal cytochrome P-450 levels and by a significant prolongation of zoxazola-mine induced paralysis times. Both changes were noted in comparison with anesthetic control values. Similar phenobarbital-halothane-treated animals were killed at 24 hr after anesthesia, and their livers were prepared for histologic evaluation. These livers invariably revealed multiple, discrete foci of parenchymal necrosis; many also displayed patchy subcapsular necrosis, as well. Equal amounts of halothane anesthesia produced neither functional impairment nor hepatic necrosis in rats pretreated with saline instead of phenobarbital.",

author = "Stenger, \{R. J.\} and Johnson, \{E. A.\}",

note = "Funding Information: Supported in part by U.S. Public Health Service Research Grant AM-13395 from the National Institute of Arthritis and Metabolic Diseases. Presented in part at the 22nd Annual Meeting of the American Association for the Study of Liver Diseases (Chicago; Nov. 3, 1971). 9 1972 140 4 1319 1324 ",

year = "1972",

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doi = "10.3181/00379727-140-36666",

language = "English",

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AU - Johnson, E. A.

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PY - 1972/9

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N2 - Administration of halothane ip to rats pretreated with phenobarbital caused hepatic functional impairment in the immediate postanesthetic period. This impairment was manifested by a significant reduction of hepatic microsomal cytochrome P-450 levels and by a significant prolongation of zoxazola-mine induced paralysis times. Both changes were noted in comparison with anesthetic control values. Similar phenobarbital-halothane-treated animals were killed at 24 hr after anesthesia, and their livers were prepared for histologic evaluation. These livers invariably revealed multiple, discrete foci of parenchymal necrosis; many also displayed patchy subcapsular necrosis, as well. Equal amounts of halothane anesthesia produced neither functional impairment nor hepatic necrosis in rats pretreated with saline instead of phenobarbital.

AB - Administration of halothane ip to rats pretreated with phenobarbital caused hepatic functional impairment in the immediate postanesthetic period. This impairment was manifested by a significant reduction of hepatic microsomal cytochrome P-450 levels and by a significant prolongation of zoxazola-mine induced paralysis times. Both changes were noted in comparison with anesthetic control values. Similar phenobarbital-halothane-treated animals were killed at 24 hr after anesthesia, and their livers were prepared for histologic evaluation. These livers invariably revealed multiple, discrete foci of parenchymal necrosis; many also displayed patchy subcapsular necrosis, as well. Equal amounts of halothane anesthesia produced neither functional impairment nor hepatic necrosis in rats pretreated with saline instead of phenobarbital.

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DO - 10.3181/00379727-140-36666

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JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 4

ER -

Effects of Phenobarbital Pretreatment on the Response of Rat Liver to Halothane Administration

Abstract

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