Objective: To study the most stable pH value of rifampicin solution and effects of three kinds of buffers on the stability of rifampicin solution. Method: The stability of rifampicin was studied by classic method. The content of rifampicin solution was determined by Chinese pharmacopoea method (1990). The figure of pH-lgk was done. Results: The most stable pH value of rifampicin solution was observed. The paired t-test for content of rifampicin indicated that rifampicin solution of acetate and borate had no significant difference (P > 0.05), but the content of phosphate and acetate or borate had significant difference (P < 0.05). Conclusion: The most stable pH value of rifampicin solution is 6.0 ~ 7.0. The laboratory findings showed that rifampicin is more stable in borate or acetate buffer than in phosphate. Phosphate makes rifampicin to break up rapidly.
|Number of pages||4|
|Journal||Chinese Pharmaceutical Journal|
|State||Published - 1996|
- most stable pH value