Effects of pH and buffers on the stability of rifampicin solution

J. Zhou, P. Wang, Y. Li

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: To study the most stable pH value of rifampicin solution and effects of three kinds of buffers on the stability of rifampicin solution. Method: The stability of rifampicin was studied by classic method. The content of rifampicin solution was determined by Chinese pharmacopoea method (1990). The figure of pH-lgk was done. Results: The most stable pH value of rifampicin solution was observed. The paired t-test for content of rifampicin indicated that rifampicin solution of acetate and borate had no significant difference (P > 0.05), but the content of phosphate and acetate or borate had significant difference (P < 0.05). Conclusion: The most stable pH value of rifampicin solution is 6.0 ~ 7.0. The laboratory findings showed that rifampicin is more stable in borate or acetate buffer than in phosphate. Phosphate makes rifampicin to break up rapidly.

Original languageEnglish
Pages (from-to)406-409
Number of pages4
JournalChinese Pharmaceutical Journal
Volume31
Issue number7
StatePublished - 1996
Externally publishedYes

Keywords

  • buffer
  • most stable pH value
  • rifampicin

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