Abstract
Objective: To study the most stable pH value of rifampicin solution and effects of three kinds of buffers on the stability of rifampicin solution. Method: The stability of rifampicin was studied by classic method. The content of rifampicin solution was determined by Chinese pharmacopoea method (1990). The figure of pH-lgk was done. Results: The most stable pH value of rifampicin solution was observed. The paired t-test for content of rifampicin indicated that rifampicin solution of acetate and borate had no significant difference (P > 0.05), but the content of phosphate and acetate or borate had significant difference (P < 0.05). Conclusion: The most stable pH value of rifampicin solution is 6.0 ~ 7.0. The laboratory findings showed that rifampicin is more stable in borate or acetate buffer than in phosphate. Phosphate makes rifampicin to break up rapidly.
| Original language | English |
|---|---|
| Pages (from-to) | 406-409 |
| Number of pages | 4 |
| Journal | Chinese Pharmaceutical Journal |
| Volume | 31 |
| Issue number | 7 |
| State | Published - 1996 |
| Externally published | Yes |
Keywords
- buffer
- most stable pH value
- rifampicin