Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat

Gregory J. Schilero; Peter Almenoff; Christopher Cardozo; Marvin Lesser

doi:10.1016/0196-9781(94)90122-8

Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat

Gregory J. Schilero, Peter Almenoff, Christopher Cardozo, Marvin Lesser

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.

Original language	English
Pages (from-to)	1445-1449
Number of pages	5
Journal	Peptides
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/0196-9781(94)90122-8
State	Published - 1994

Keywords

Angiotensin-converting enzyme
Bradykinin
Enalaprilat
Endopeptidase 24.11
Kininases
Kinins
Metallopeptidases
Phosphoramidon

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10.1016/0196-9781(94)90122-8

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title = "Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat",

abstract = "Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.",

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T1 - Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat

AU - Schilero, Gregory J.

AU - Almenoff, Peter

AU - Cardozo, Christopher

AU - Lesser, Marvin

PY - 1994

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N2 - Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.

AB - Objectives of this study were to determine if aerosolized bradykinin causes bronchoconstriction in anesthetized, mechanically ventilated rats, and if pretreatment with enalaprilat, an inhibitor of angiotensin-converting enzyme (ACE), or phosphoramidon, an inhibitor of endopeptidase 24.11 (EP 24.11), alters the response. We found that aerosolized bradykinin elicited a reproducible bronchoconstrictor response that was significantly amplified by pretreatment with aerosolized enalaprilat or phosphoramidon. Neither inhibitor alone affected airway tone or caused nonspecific airway hyperreactivity. These findings indicate that both ACE and EP 24.11 contribute to bradykinin degradation in rat airways.

KW - Angiotensin-converting enzyme

KW - Bradykinin

KW - Enalaprilat

KW - Endopeptidase 24.11

KW - Kininases

KW - Kinins

KW - Metallopeptidases

KW - Phosphoramidon

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ER -

Effects of peptidase inhibitors on bradykinin-induced bronchoconstriction in the rat

Abstract

Keywords

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