Effects of parental anxiety disorders in children at high risk for panic disorder: A controlled study

Joseph Biederman, Carter Petty, Stephen V. Faraone, Aude Henin, Dina Hirshfeld-Becker, Mark H. Pollack, Sophie de Figueiredo, Robert Feeley, Jerrold F. Rosenbaum

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Background: To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring. Methods: Comparisons were made between offspring of parents with PD + MD (N = 136), PD (N = 27), MD (N = 27), and Controls (N = 103). All subjects were assessed with structured diagnostic interviews. Individual anxiety disorders in the offspring were used as dependent variables in logistic regression models where parental PD status, parental MD, and the same parental anxiety diagnosis were used as independent binary variables. Results: Social phobia and separation anxiety disorder in the offspring were accounted for by the same disorders in the parent, whereas agoraphobia and OCD in the offspring were accounted for by parental panic disorder. Conclusions: These findings suggest that differing risk factors underlie the expression of individual anxiety disorders in children at risk for panic disorder.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalJournal of Affective Disorders
Volume94
Issue number1-3
DOIs
StatePublished - Aug 2006
Externally publishedYes

Keywords

  • Anxiety
  • Children
  • Family
  • Panic disorder

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