Effects of p21 deletion in mouse models of premature aging

Erica K. Benson; Bo Zhao; David A. Sassoon; Sam W. Lee; Stuart A. Aaronson

doi:10.4161/cc.8.13.8997

Effects of p21 deletion in mouse models of premature aging

Erica K. Benson, Bo Zhao, David A. Sassoon, Sam W. Lee, Stuart A. Aaronson

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

An approach to investigate the role of cellular senescence in organismal aging has been to abrogate signaling pathways known to induce cellular senescence and to assess the effects in mouse models of premature aging. Recently, we reported the effect of loss of function of p21, a gene implicated in p53-induced cellular senescence, in the background of the Ku80-/- premature aging mouse (Zhao et al., EMBO Rep 2009). Here, we provide an overview of the effects of p21 deletion in different models of premature aging.

Original language	English
Pages (from-to)	2002-2004
Number of pages	3
Journal	Cell Cycle
Volume	8
Issue number	13
DOIs	https://doi.org/10.4161/cc.8.13.8997
State	Published - 1 Jul 2009

Keywords

ATM
Cellular senescence
Ku80
Premature aging
TERC
Tumorigenesis
p21

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title = "Effects of p21 deletion in mouse models of premature aging",

abstract = "An approach to investigate the role of cellular senescence in organismal aging has been to abrogate signaling pathways known to induce cellular senescence and to assess the effects in mouse models of premature aging. Recently, we reported the effect of loss of function of p21, a gene implicated in p53-induced cellular senescence, in the background of the Ku80-/- premature aging mouse (Zhao et al., EMBO Rep 2009). Here, we provide an overview of the effects of p21 deletion in different models of premature aging.",

keywords = "ATM, Cellular senescence, Ku80, Premature aging, TERC, Tumorigenesis, p21",

author = "Benson, {Erica K.} and Bo Zhao and Sassoon, {David A.} and Lee, {Sam W.} and Aaronson, {Stuart A.}",

note = "Funding Information: This work was supported by grant number PO1CA80058 from the National Cancer Institute.",

year = "2009",

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doi = "10.4161/cc.8.13.8997",

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TY - JOUR

T1 - Effects of p21 deletion in mouse models of premature aging

AU - Benson, Erica K.

AU - Zhao, Bo

AU - Sassoon, David A.

AU - Lee, Sam W.

AU - Aaronson, Stuart A.

N1 - Funding Information: This work was supported by grant number PO1CA80058 from the National Cancer Institute.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - An approach to investigate the role of cellular senescence in organismal aging has been to abrogate signaling pathways known to induce cellular senescence and to assess the effects in mouse models of premature aging. Recently, we reported the effect of loss of function of p21, a gene implicated in p53-induced cellular senescence, in the background of the Ku80-/- premature aging mouse (Zhao et al., EMBO Rep 2009). Here, we provide an overview of the effects of p21 deletion in different models of premature aging.

AB - An approach to investigate the role of cellular senescence in organismal aging has been to abrogate signaling pathways known to induce cellular senescence and to assess the effects in mouse models of premature aging. Recently, we reported the effect of loss of function of p21, a gene implicated in p53-induced cellular senescence, in the background of the Ku80-/- premature aging mouse (Zhao et al., EMBO Rep 2009). Here, we provide an overview of the effects of p21 deletion in different models of premature aging.

KW - ATM

KW - Cellular senescence

KW - Ku80

KW - Premature aging

KW - TERC

KW - Tumorigenesis

KW - p21

UR - http://www.scopus.com/inward/record.url?scp=67650514086&partnerID=8YFLogxK

U2 - 10.4161/cc.8.13.8997

DO - 10.4161/cc.8.13.8997

M3 - Short survey

C2 - 19535900

AN - SCOPUS:67650514086

SN - 1538-4101

VL - 8

SP - 2002

EP - 2004

JO - Cell Cycle

JF - Cell Cycle

IS - 13

ER -

Effects of p21 deletion in mouse models of premature aging

Abstract

Keywords

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