Effects of olmesartan-based treatment on masked, white-coat, poorly controlled, and well-controlled hypertension: HONEST study

Kazuomi Kario, Ikuo Saito, Toshio Kushiro, Satoshi Teramukai, Yusuke Ishikawa, Fumiaki Kobayashi, Kazuyuki Shimada

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The authors examined the effects of olmesartan-based treatment on clinic systolic blood pressure (CSBP) and morning home systolic blood pressure (HSBP) in 21,340 patients with masked hypertension (MH), white-coat hypertension (WCH), poorly controlled hypertension (PCH), and well-controlled hypertension (CH) using data from the Home Blood Pressure Measurement With Olmesartan Naive Patients to Establish Standard Target Blood Pressure (HONEST) study. MH, WCH, PCH, and CH were defined using CSBP 140 mm Hg and MHSBP 135 mm Hg as cutoff values at baseline. At 16 weeks, the MH, WCH, PCH, and CH groups had changes in CSBP by -1.0, -15.2, -23.1, and 1.8 mm Hg, and changes in morning HSBP by -12.5, 1.0, -20.3, and 2.0 mm Hg, respectively. In conclusion, in "real-world" clinical practice, olmesartan-based treatment decreased high morning HBP or CBP without excessive decreases in normal morning HBP or CBP according to patients' BP status.

Original languageEnglish
Pages (from-to)442-450
Number of pages9
JournalJournal of Clinical Hypertension
Volume16
Issue number6
DOIs
StatePublished - Jun 2014
Externally publishedYes

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