Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens

Shafiqur Rahman; Jianhua Zhang; William A. Corrigall

doi:10.1016/j.ejphar.2004.04.044

Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens

Shafiqur Rahman
, Jianhua Zhang
, William A. Corrigall

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We examined the effects of nicotine preexposure or saline on dopamine release to sulpiride in the rat nucleus accumbens. Microdialysis was used to locally perfuse the sulpiride into the ventral tegmental area while sampling dopamine levels in the nucleus accumbens. The increase (130% and 165% of basal) in extracellular accumbens dopamine levels observed during ventral tegmental area perfusion for 80 min with 10-100 μM sulpiride in saline-treated animals was reduced (128% and 105% of basal) in nicotine-preexposed animals. The reduction of sulpiride-induced nucleus accumbens dopamine release after nicotine treatment is likely the result of down-regulation of somatodendritic dopamine autoreceptors.

Original language	English
Pages (from-to)	31-34
Number of pages	4
Journal	European Journal of Pharmacology
Volume	494
Issue number	1
DOIs	https://doi.org/10.1016/j.ejphar.2004.04.044
State	Published - 21 Jun 2004
Externally published	Yes

Keywords

Dopamine autoreceptor
Dopamine release
In vivo microdialysis
Nicotine
Nucleus accumbens
Ventral tegmental area

Access to Document

10.1016/j.ejphar.2004.04.044

Cite this

@article{fffb799a08994d94804e32c7ea9cfd55,

title = "Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens",

abstract = "We examined the effects of nicotine preexposure or saline on dopamine release to sulpiride in the rat nucleus accumbens. Microdialysis was used to locally perfuse the sulpiride into the ventral tegmental area while sampling dopamine levels in the nucleus accumbens. The increase (130\% and 165\% of basal) in extracellular accumbens dopamine levels observed during ventral tegmental area perfusion for 80 min with 10-100 μM sulpiride in saline-treated animals was reduced (128\% and 105\% of basal) in nicotine-preexposed animals. The reduction of sulpiride-induced nucleus accumbens dopamine release after nicotine treatment is likely the result of down-regulation of somatodendritic dopamine autoreceptors.",

keywords = "Dopamine autoreceptor, Dopamine release, In vivo microdialysis, Nicotine, Nucleus accumbens, Ventral tegmental area",

author = "Shafiqur Rahman and Jianhua Zhang and Corrigall, \{William A.\}",

note = "Funding Information: The experiments were supported in part by funds from the NIDA. The authors thank Dr. Eric Engleman for helpful comments.",

year = "2004",

month = jun,

day = "21",

doi = "10.1016/j.ejphar.2004.04.044",

language = "English",

volume = "494",

pages = "31--34",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens

AU - Rahman, Shafiqur

AU - Zhang, Jianhua

AU - Corrigall, William A.

N1 - Funding Information: The experiments were supported in part by funds from the NIDA. The authors thank Dr. Eric Engleman for helpful comments.

PY - 2004/6/21

Y1 - 2004/6/21

N2 - We examined the effects of nicotine preexposure or saline on dopamine release to sulpiride in the rat nucleus accumbens. Microdialysis was used to locally perfuse the sulpiride into the ventral tegmental area while sampling dopamine levels in the nucleus accumbens. The increase (130% and 165% of basal) in extracellular accumbens dopamine levels observed during ventral tegmental area perfusion for 80 min with 10-100 μM sulpiride in saline-treated animals was reduced (128% and 105% of basal) in nicotine-preexposed animals. The reduction of sulpiride-induced nucleus accumbens dopamine release after nicotine treatment is likely the result of down-regulation of somatodendritic dopamine autoreceptors.

AB - We examined the effects of nicotine preexposure or saline on dopamine release to sulpiride in the rat nucleus accumbens. Microdialysis was used to locally perfuse the sulpiride into the ventral tegmental area while sampling dopamine levels in the nucleus accumbens. The increase (130% and 165% of basal) in extracellular accumbens dopamine levels observed during ventral tegmental area perfusion for 80 min with 10-100 μM sulpiride in saline-treated animals was reduced (128% and 105% of basal) in nicotine-preexposed animals. The reduction of sulpiride-induced nucleus accumbens dopamine release after nicotine treatment is likely the result of down-regulation of somatodendritic dopamine autoreceptors.

KW - Dopamine autoreceptor

KW - Dopamine release

KW - In vivo microdialysis

KW - Nicotine

KW - Nucleus accumbens

KW - Ventral tegmental area

UR - https://www.scopus.com/pages/publications/2942607504

U2 - 10.1016/j.ejphar.2004.04.044

DO - 10.1016/j.ejphar.2004.04.044

M3 - Article

C2 - 15194448

AN - SCOPUS:2942607504

SN - 0014-2999

VL - 494

SP - 31

EP - 34

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens

Abstract

Keywords

Access to Document

Fingerprint

Cite this