Effects of naloxone on corticosterone response to stress

Walter N. Tapp; James C. Mittler; Benjamin H. Natelson

doi:10.1016/0091-3057(81)90143-X

Effects of naloxone on corticosterone response to stress

Walter N. Tapp, James C. Mittler, Benjamin H. Natelson

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The effect of naloxone on the corticosterone response to restraint stress was examined. Naloxone (8 mg/kg, IP) did not alter basal corticosterone or the magnitude of the corticosterone response to restraint stress. Naloxone did, however, retard the fall in corticosterone following the end of restraint stress; thus the drug prolonged the stress response. These data suggest that endogenous opiates play a role in the restoration of corticosterone levels back to normal after stress.

Original language	English
Pages (from-to)	749-751
Number of pages	3
Journal	Pharmacology Biochemistry and Behavior
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(81)90143-X
State	Published - May 1981
Externally published	Yes

Keywords

Corticosterone
Naloxone
Stress

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10.1016/0091-3057(81)90143-X

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abstract = "The effect of naloxone on the corticosterone response to restraint stress was examined. Naloxone (8 mg/kg, IP) did not alter basal corticosterone or the magnitude of the corticosterone response to restraint stress. Naloxone did, however, retard the fall in corticosterone following the end of restraint stress; thus the drug prolonged the stress response. These data suggest that endogenous opiates play a role in the restoration of corticosterone levels back to normal after stress.",

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AU - Mittler, James C.

AU - Natelson, Benjamin H.

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AB - The effect of naloxone on the corticosterone response to restraint stress was examined. Naloxone (8 mg/kg, IP) did not alter basal corticosterone or the magnitude of the corticosterone response to restraint stress. Naloxone did, however, retard the fall in corticosterone following the end of restraint stress; thus the drug prolonged the stress response. These data suggest that endogenous opiates play a role in the restoration of corticosterone levels back to normal after stress.

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KW - Naloxone

KW - Stress

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Effects of naloxone on corticosterone response to stress

Abstract

Keywords

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