TY - JOUR
T1 - Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus
AU - Stirban, Alin
AU - Nandrean, Simona
AU - Götting, Christian
AU - Tamler, Ronald
AU - Pop, Alexandra
AU - Negrean, Monica
AU - Gawlowski, Thomas
AU - Stratmann, Bernd
AU - Tschoepe, Diethelm
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Background: Recent evidence supports the protective effects of n - 3 (omega-3) fatty acids (n - 3 FAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on vascular function. Objective: We investigated the effects of EPA and DHA on post-prandial vascular function in subjects with type 2 diabetes mellitus. Design: In a double-blind, placebo-controlled, randomized, crossover manner, 34 subjects with type 2 diabetes mellitus received daily either 2 g purified EPA/DHA (termed n - 3 FAs) or olive oil (placebo) for 6 wk. At the end of this period, we measured macrovascular (brachial ultrasound of flow-mediated dilatation; FMD) and microvascular [laser-Doppler measurements of reactive hyperemia (RH) of the hand] function at fasting and 2, 4, and 6 h after a highfat meal (600 kcal, 21 g protein, 41 g carbohydrates, 40 g fat). Results: Fasting vascular function remained unchanged after n - 3 FAs and placebo. Postprandial FMD decreased from fasting after placebo, with a maximum decrease (38%) at 4 h - an effect that was significantly reduced (P = 0.03 for time • treatment interaction) by n - 3 FA supplementation (maximum decrease in FMD was at 4 h: 13%). RH remained unchanged after placebo, whereas it improved significantly (P = 0.04 for time • treatment interaction) after n - 3 FA supplementation (maximum increase was at 2 h: 27%). Conclusions: In subjects with type 2 diabetes mellitus, 6 wk of supplementation with n - 3 FAs reduced the postprandial decrease in macrovascular function relative to placebo. Moreover, n - 3 FA supplementation improved postprandial microvascular function. These observations suggest a protective vascular effect of n - 3 FAs.
AB - Background: Recent evidence supports the protective effects of n - 3 (omega-3) fatty acids (n - 3 FAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on vascular function. Objective: We investigated the effects of EPA and DHA on post-prandial vascular function in subjects with type 2 diabetes mellitus. Design: In a double-blind, placebo-controlled, randomized, crossover manner, 34 subjects with type 2 diabetes mellitus received daily either 2 g purified EPA/DHA (termed n - 3 FAs) or olive oil (placebo) for 6 wk. At the end of this period, we measured macrovascular (brachial ultrasound of flow-mediated dilatation; FMD) and microvascular [laser-Doppler measurements of reactive hyperemia (RH) of the hand] function at fasting and 2, 4, and 6 h after a highfat meal (600 kcal, 21 g protein, 41 g carbohydrates, 40 g fat). Results: Fasting vascular function remained unchanged after n - 3 FAs and placebo. Postprandial FMD decreased from fasting after placebo, with a maximum decrease (38%) at 4 h - an effect that was significantly reduced (P = 0.03 for time • treatment interaction) by n - 3 FA supplementation (maximum decrease in FMD was at 4 h: 13%). RH remained unchanged after placebo, whereas it improved significantly (P = 0.04 for time • treatment interaction) after n - 3 FA supplementation (maximum increase was at 2 h: 27%). Conclusions: In subjects with type 2 diabetes mellitus, 6 wk of supplementation with n - 3 FAs reduced the postprandial decrease in macrovascular function relative to placebo. Moreover, n - 3 FA supplementation improved postprandial microvascular function. These observations suggest a protective vascular effect of n - 3 FAs.
UR - http://www.scopus.com/inward/record.url?scp=77749264445&partnerID=8YFLogxK
U2 - 10.3945/ajcn.2009.28374
DO - 10.3945/ajcn.2009.28374
M3 - Article
C2 - 20071644
AN - SCOPUS:77749264445
SN - 0002-9165
VL - 91
SP - 808
EP - 813
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 3
ER -