Effects of mitomycin-c and etoposide in cell culture and in nude mice: The role of g-CSF mutein

Masato Fujii; Takao Ohnuma; Lenina Szrajer; James F. Holland; Hugh Biller; Masami Okabe

doi:10.3109/07357909309024853

Effects of mitomycin-c and etoposide in cell culture and in nude mice: The role of g-CSF mutein

Masato Fujii
, Takao Ohnuma
, Lenina Szrajer
, James F. Holland
, Hugh Biller
, Masami Okabe

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The combination of mitomycin-C and etopzoside showed synergistic cell kill effects in vitro against HEp-2 laryngeal squatnous carcinoma cells both in monolayer and in multicellular tumor spheroid systems. This cornbination was also synergistic in inhibiting HEp-2 tumors growing in nude mice. One course of this combination produced no complete regression of this tumor. When these two agents were combined with recombinant human granulocyte colony-stimulating factor (G-CSF) mutein, the doses of the drugs could be escalated approximately 1.5-fold higher than the doses that were tolerated without G-CSF support. With this modest close intensication, apparent cure MWS observed. High-dose mitomycin-C plus etoposide with G-CSF support may be useful, for the treatment of patients with inoperable squamous cell carcinoma of the head and neck.

Original language	English
Pages (from-to)	283-290
Number of pages	8
Journal	Cancer Investigation
Volume	11
Issue number	3
DOIs	https://doi.org/10.3109/07357909309024853
State	Published - 1993

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@article{472a543c427d45d2823d82e5399e4782,

title = "Effects of mitomycin-c and etoposide in cell culture and in nude mice: The role of g-CSF mutein",

abstract = "The combination of mitomycin-C and etopzoside showed synergistic cell kill effects in vitro against HEp-2 laryngeal squatnous carcinoma cells both in monolayer and in multicellular tumor spheroid systems. This cornbination was also synergistic in inhibiting HEp-2 tumors growing in nude mice. One course of this combination produced no complete regression of this tumor. When these two agents were combined with recombinant human granulocyte colony-stimulating factor (G-CSF) mutein, the doses of the drugs could be escalated approximately 1.5-fold higher than the doses that were tolerated without G-CSF support. With this modest close intensication, apparent cure MWS observed. High-dose mitomycin-C plus etoposide with G-CSF support may be useful, for the treatment of patients with inoperable squamous cell carcinoma of the head and neck.",

author = "Masato Fujii and Takao Ohnuma and Lenina Szrajer and Holland, \{James F.\} and Hugh Biller and Masami Okabe",

note = "Funding Information: This work was supported in part by the Chemotherapy Foundation, Inc., New York, NY: by the United Leukemia Fund. Inc., Rego Park, NY: and by the T. J. Martell Foundation for Cancer and Leukemia Research. New York, NY.",

year = "1993",

doi = "10.3109/07357909309024853",

language = "English",

volume = "11",

pages = "283--290",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor \& Francis Group LLC Philadelphia",

number = "3",

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TY - JOUR

T1 - Effects of mitomycin-c and etoposide in cell culture and in nude mice

T2 - The role of g-CSF mutein

AU - Fujii, Masato

AU - Ohnuma, Takao

AU - Szrajer, Lenina

AU - Holland, James F.

AU - Biller, Hugh

AU - Okabe, Masami

N1 - Funding Information: This work was supported in part by the Chemotherapy Foundation, Inc., New York, NY: by the United Leukemia Fund. Inc., Rego Park, NY: and by the T. J. Martell Foundation for Cancer and Leukemia Research. New York, NY.

PY - 1993

Y1 - 1993

N2 - The combination of mitomycin-C and etopzoside showed synergistic cell kill effects in vitro against HEp-2 laryngeal squatnous carcinoma cells both in monolayer and in multicellular tumor spheroid systems. This cornbination was also synergistic in inhibiting HEp-2 tumors growing in nude mice. One course of this combination produced no complete regression of this tumor. When these two agents were combined with recombinant human granulocyte colony-stimulating factor (G-CSF) mutein, the doses of the drugs could be escalated approximately 1.5-fold higher than the doses that were tolerated without G-CSF support. With this modest close intensication, apparent cure MWS observed. High-dose mitomycin-C plus etoposide with G-CSF support may be useful, for the treatment of patients with inoperable squamous cell carcinoma of the head and neck.

AB - The combination of mitomycin-C and etopzoside showed synergistic cell kill effects in vitro against HEp-2 laryngeal squatnous carcinoma cells both in monolayer and in multicellular tumor spheroid systems. This cornbination was also synergistic in inhibiting HEp-2 tumors growing in nude mice. One course of this combination produced no complete regression of this tumor. When these two agents were combined with recombinant human granulocyte colony-stimulating factor (G-CSF) mutein, the doses of the drugs could be escalated approximately 1.5-fold higher than the doses that were tolerated without G-CSF support. With this modest close intensication, apparent cure MWS observed. High-dose mitomycin-C plus etoposide with G-CSF support may be useful, for the treatment of patients with inoperable squamous cell carcinoma of the head and neck.

UR - https://www.scopus.com/pages/publications/0027199979

U2 - 10.3109/07357909309024853

DO - 10.3109/07357909309024853

M3 - Article

C2 - 7683568

AN - SCOPUS:0027199979

SN - 0735-7907

VL - 11

SP - 283

EP - 290

JO - Cancer Investigation

JF - Cancer Investigation

IS - 3

ER -

Effects of mitomycin-c and etoposide in cell culture and in nude mice: The role of g-CSF mutein

Abstract

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