Effects of Mithramycin on Bone Resorption in Vitro

Engracio P. Cortes; James F. Holland; Robert Moskowitz; Euro Depoli

Effects of Mithramycin on Bone Resorption in Vitro

Engracio P. Cortes, James F. Holland, Robert Moskowitz, Euro Depoli

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Embryonic rat bones labeled with^{4 5}^CaCl₂are stimulated in vitro by parathyroid extract to release⁴⁵Ca. Mithramycin prevents this active release over a broad range of dose levels that are nonlethal to the bones, as evidenced by their subsequent responsiveness to additional parathyroid extract. The similarity of dose levels used to concentrations (based on calculated dilution) after clinical administration supports the interpretation that clinical effects of mithramycin in hypercalcemic patients are due to a direct effect on bone.

Original language	English
Pages (from-to)	74-76
Number of pages	3
Journal	Cancer Research
Volume	32
Issue number	1
State	Published - Jan 1972
Externally published	Yes

Cite this

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title = "Effects of Mithramycin on Bone Resorption in Vitro",

abstract = "Embryonic rat bones labeled with4 5CaCl2are stimulated in vitro by parathyroid extract to release45Ca. Mithramycin prevents this active release over a broad range of dose levels that are nonlethal to the bones, as evidenced by their subsequent responsiveness to additional parathyroid extract. The similarity of dose levels used to concentrations (based on calculated dilution) after clinical administration supports the interpretation that clinical effects of mithramycin in hypercalcemic patients are due to a direct effect on bone.",

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year = "1972",

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N2 - Embryonic rat bones labeled with4 5CaCl2are stimulated in vitro by parathyroid extract to release45Ca. Mithramycin prevents this active release over a broad range of dose levels that are nonlethal to the bones, as evidenced by their subsequent responsiveness to additional parathyroid extract. The similarity of dose levels used to concentrations (based on calculated dilution) after clinical administration supports the interpretation that clinical effects of mithramycin in hypercalcemic patients are due to a direct effect on bone.

AB - Embryonic rat bones labeled with4 5CaCl2are stimulated in vitro by parathyroid extract to release45Ca. Mithramycin prevents this active release over a broad range of dose levels that are nonlethal to the bones, as evidenced by their subsequent responsiveness to additional parathyroid extract. The similarity of dose levels used to concentrations (based on calculated dilution) after clinical administration supports the interpretation that clinical effects of mithramycin in hypercalcemic patients are due to a direct effect on bone.

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Effects of Mithramycin on Bone Resorption in Vitro

Abstract

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