TY - JOUR
T1 - Effects of lifestyle factors on leukocytes in cardiovascular health and disease
AU - Janssen, Henrike
AU - Koekkoek, Laura L.
AU - Swirski, Filip K.
N1 - Publisher Copyright:
© Springer Nature Limited 2023.
PY - 2024/3
Y1 - 2024/3
N2 - Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have underscored the importance of managing stress, having good sleep hygiene and responsible eating habits and exercising regularly. We are born with a genetic blueprint that can protect us against or predispose us to a particular disease. However, lifestyle factors build upon and profoundly influence those predispositions. Studies in the past 10 years have shown that the immune system in general and leukocytes in particular are particularly susceptible to environmental perturbations. Lifestyle factors such as stress, sleep, diet and exercise affect leukocyte behaviour and function and thus the immune system at large. In this Review, we explore the various mechanisms by which lifestyle factors modulate haematopoiesis and leukocyte migration and function in the context of cardiovascular health. We pay particular attention to the role of the nervous system as the key executor that connects environmental influences to leukocyte behaviour.
AB - Exercise, stress, sleep and diet are four distinct but intertwined lifestyle factors that influence the cardiovascular system. Abundant epidemiological, clinical and preclinical studies have underscored the importance of managing stress, having good sleep hygiene and responsible eating habits and exercising regularly. We are born with a genetic blueprint that can protect us against or predispose us to a particular disease. However, lifestyle factors build upon and profoundly influence those predispositions. Studies in the past 10 years have shown that the immune system in general and leukocytes in particular are particularly susceptible to environmental perturbations. Lifestyle factors such as stress, sleep, diet and exercise affect leukocyte behaviour and function and thus the immune system at large. In this Review, we explore the various mechanisms by which lifestyle factors modulate haematopoiesis and leukocyte migration and function in the context of cardiovascular health. We pay particular attention to the role of the nervous system as the key executor that connects environmental influences to leukocyte behaviour.
UR - http://www.scopus.com/inward/record.url?scp=85172673056&partnerID=8YFLogxK
U2 - 10.1038/s41569-023-00931-w
DO - 10.1038/s41569-023-00931-w
M3 - Review article
C2 - 37752350
AN - SCOPUS:85172673056
SN - 1759-5002
VL - 21
SP - 157
EP - 169
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 3
ER -