Effects of lead and other cations on pial arteries of the mouse

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BaCl2 caused marked constriction of pial arteries when topically applied to the cerebral surface of the living mouse. Mg, Sr, Ca, Zn and Pb failed to elicit similar responses. Mg and Sr dilated pial arteries but these effects were not distinguishable from those of control solutions of similar ionic strength. Ca dilated these vessels and also had a modest inhibitory effect on the contractile response to barium. Zn and Pb produced marked dilation of the pial arteries and profound inhibition of the contractile response to barium. Lead was tested in various dose levels and its effects were reversible at lower concentrations. These observations were discussed in terms of the ionic responses of other smooth muscles. The effects of lead indicated that pial arteries respond differently to this ion than does smooth muscle at other sites. The results fail to support the hypothesis that lead would constrict cerebral vessels.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalActa Neuropathologica
Issue number1
StatePublished - Mar 1965
Externally publishedYes


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