Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression

Rebecca B. Price, Matthew K. Nock, Dennis S. Charney, Sanjay J. Mathew

Research output: Contribution to journalArticlepeer-review

513 Scopus citations

Abstract

Background: Intravenous ketamine has shown rapid antidepressant effects in early trials, making it a potentially attractive candidate for depressed patients at imminent risk of suicide. The Implicit Association Test (IAT), a performance-based measure of association between concepts, may have utility in suicide assessment. Methods: Twenty-six patients with treatment-resistant depression were assessed using the suicidality item of the Montgomery-Asberg Depression Rating Scale (MADRS-SI) 2 hours before and 24 hours following a single subanesthetic dose of intravenous ketamine. Ten patients also completed IATs assessing implicit suicidal associations at comparable time points. In a second study, nine patients received thrice-weekly ketamine infusions over a 12-day period. Results: Twenty-four hours after a single infusion, MADRS-SI scores were reduced on average by 2.08 points on a 0 to 6 scale (p < .001; d = 1.37), and 81% of patients received a rating of 0 or 1 postinfusion. Implicit suicidal associations were also reduced following ketamine (p = .003; d = 1.36), with reductions correlated across implicit and explicit measures. MADRS-SI reductions were sustained for 12 days by repeated-dose ketamine (p < .001; d = 2.42). Conclusions: These preliminary findings support the premise that ketamine has rapid beneficial effects on suicidal cognition and warrants further study.

Original languageEnglish
Pages (from-to)522-526
Number of pages5
JournalBiological Psychiatry
Volume66
Issue number5
DOIs
StatePublished - 1 Sep 2009

Keywords

  • Implicit association test
  • ketamine
  • suicide

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