@article{55ccb6180e284012a964405c8ba00dd1,
title = "Effects of Increased Blood Pressure on Cerebral Vessels in Mice",
author = "Rosenblum, \{William I.\} and Hyman Donnenfeld and Fernando Aleu",
note = "Funding Information: factors. Acuteelevationsofbloodpressuredid not alter thesensitivityofpialvesselsto topically appliedconstrictoragents.The amount of dilatationproducedbytopical nylidrinHC1 increasedduringperiods of elevated pressure. Miceweremadechronicallyhypertensive withDOCAandNaCl.Vascularrenal lesions andanincreaseinheartweightwere noted. Convulsions,paralysis,orlethargy recognized,although waspresent.Thepialvesselscerebraloftheseedemamice behavedlikethevesselsofcontrolanimals withrespecttotheirreactionsafterabrupt elevationsofbloodpressureandtheirsen¬ sitivitytolocallyappliedcontractileagents. Ourdatafailtosupporthypothesisthethat chronichypertension is accompanied by an increased vascularreactivityonthepartof cerebral vessels orthat hypertension results invasospasmwithconsequentcerebral edema.Ourdataindicatethatthepresence of cerebral edema in chronic hypertension need not be accompanied by recognizable neurologicsymptoms. Theauthorsacknowledgethetechnicalassistance ofMissPatriciaOssip. This work was supported inpartbyUSPublic Health ServicegrantHD01414-01,grantsfromthe USVitaminandPharmaceuticalCorporation,New York,andtheAmericanMedicalAssociation,and by the following grants from the National In¬ stituteofNeurologicalDiseasesand1Blindness:NB specialfellowshipsinneuropathology, Fll 1261-01A1NSRB(Dr.Rosenblum)and1FllNB 1369-01A1NSRB(Dr.Donnenfeld),andCareer DevelopmentAwardNB25,406-01(Dr.Aleu). Thepressuregaugesandmultichannelpolygraph mentionedinMethodsweremanufacturedby StathamandOffner,respectively.Themicroscope utilizingincidentlightmentionedundertheside- headInVivoStudieswasmanufacturedbyLeitz Ultropak.",
year = "1966",
month = jun,
doi = "10.1001/archneur.1966.00470120063010",
language = "English",
volume = "14",
pages = "631--643",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "6",
}