Effects of Increased Blood Pressure on Cerebral Vessels in Mice

William I. Rosenblum; Hyman Donnenfeld; Fernando Aleu

doi:10.1001/archneur.1966.00470120063010

Effects of Increased Blood Pressure on Cerebral Vessels in Mice

William I. Rosenblum, Hyman Donnenfeld, Fernando Aleu

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Original language	English
Pages (from-to)	631-643
Number of pages	13
Journal	Archives of Neurology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1001/archneur.1966.00470120063010
State	Published - Jun 1966
Externally published	Yes

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10.1001/archneur.1966.00470120063010

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@article{55ccb6180e284012a964405c8ba00dd1,

title = "Effects of Increased Blood Pressure on Cerebral Vessels in Mice",

author = "Rosenblum, {William I.} and Hyman Donnenfeld and Fernando Aleu",

note = "Funding Information: factors. Acuteelevationsofbloodpressuredid not alter thesensitivityofpialvesselsto topically appliedconstrictoragents.The amount of dilatationproducedbytopical nylidrinHC1 increasedduringperiods of elevated pressure. Miceweremadechronicallyhypertensive withDOCAandNaCl.Vascularrenal lesions andanincreaseinheartweightwere noted. Convulsions,paralysis,orlethargy recognized,although waspresent.Thepialvesselscerebraloftheseedemamice behavedlikethevesselsofcontrolanimals withrespecttotheirreactionsafterabrupt elevationsofbloodpressureandtheirsen¬ sitivitytolocallyappliedcontractileagents. Ourdatafailtosupporthypothesisthethat chronichypertension is accompanied by an increased vascularreactivityonthepartof cerebral vessels orthat hypertension results invasospasmwithconsequentcerebral edema.Ourdataindicatethatthepresence of cerebral edema in chronic hypertension need not be accompanied by recognizable neurologicsymptoms. Theauthorsacknowledgethetechnicalassistance ofMissPatriciaOssip. This work was supported inpartbyUSPublic Health ServicegrantHD01414-01,grantsfromthe USVitaminandPharmaceuticalCorporation,New York,andtheAmericanMedicalAssociation,and by the following grants from the National In¬ stituteofNeurologicalDiseasesand1Blindness:NB specialfellowshipsinneuropathology, Fll 1261-01A1NSRB(Dr.Rosenblum)and1FllNB 1369-01A1NSRB(Dr.Donnenfeld),andCareer DevelopmentAwardNB25,406-01(Dr.Aleu). Thepressuregaugesandmultichannelpolygraph mentionedinMethodsweremanufacturedby StathamandOffner,respectively.Themicroscope utilizingincidentlightmentionedundertheside- headInVivoStudieswasmanufacturedbyLeitz Ultropak.",

year = "1966",

month = jun,

doi = "10.1001/archneur.1966.00470120063010",

language = "English",

volume = "14",

pages = "631--643",

journal = "Archives of Neurology",

issn = "0003-9942",

publisher = "American Medical Association",

number = "6",

}

TY - JOUR

T1 - Effects of Increased Blood Pressure on Cerebral Vessels in Mice

AU - Rosenblum, William I.

AU - Donnenfeld, Hyman

AU - Aleu, Fernando

N1 - Funding Information: factors. Acuteelevationsofbloodpressuredid not alter thesensitivityofpialvesselsto topically appliedconstrictoragents.The amount of dilatationproducedbytopical nylidrinHC1 increasedduringperiods of elevated pressure. Miceweremadechronicallyhypertensive withDOCAandNaCl.Vascularrenal lesions andanincreaseinheartweightwere noted. Convulsions,paralysis,orlethargy recognized,although waspresent.Thepialvesselscerebraloftheseedemamice behavedlikethevesselsofcontrolanimals withrespecttotheirreactionsafterabrupt elevationsofbloodpressureandtheirsen¬ sitivitytolocallyappliedcontractileagents. Ourdatafailtosupporthypothesisthethat chronichypertension is accompanied by an increased vascularreactivityonthepartof cerebral vessels orthat hypertension results invasospasmwithconsequentcerebral edema.Ourdataindicatethatthepresence of cerebral edema in chronic hypertension need not be accompanied by recognizable neurologicsymptoms. Theauthorsacknowledgethetechnicalassistance ofMissPatriciaOssip. This work was supported inpartbyUSPublic Health ServicegrantHD01414-01,grantsfromthe USVitaminandPharmaceuticalCorporation,New York,andtheAmericanMedicalAssociation,and by the following grants from the National In¬ stituteofNeurologicalDiseasesand1Blindness:NB specialfellowshipsinneuropathology, Fll 1261-01A1NSRB(Dr.Rosenblum)and1FllNB 1369-01A1NSRB(Dr.Donnenfeld),andCareer DevelopmentAwardNB25,406-01(Dr.Aleu). Thepressuregaugesandmultichannelpolygraph mentionedinMethodsweremanufacturedby StathamandOffner,respectively.Themicroscope utilizingincidentlightmentionedundertheside- headInVivoStudieswasmanufacturedbyLeitz Ultropak.

PY - 1966/6

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