TY - JOUR
T1 - Effects of haloperidol challenge on regional cerebral glucose utilization in normal human subjects
AU - Bartlett, Elsa J.
AU - Brodie, Jonathan D.
AU - Simkowitz, Philip
AU - Dewey, Stephen L.
AU - Rusinek, Henry
AU - Wolf, Alfred P.
AU - Fowler, Joanna S.
AU - Volkow, Nora D.
AU - Smith, Gwenn
AU - Wolkin, Adam
AU - Cancro, Robert
PY - 1994/5
Y1 - 1994/5
N2 - Objective: Positron emission tomography and the fluorodeoxyglucose (FDG) method were used to determine the brain's metabolic response to neuroleptic challenge in a normal, disease-free state. Method: FDG measurements were obtained before and 12 hours after administration of 5 mg of haloperidol to 12 young normal men. These values were compared with test-retest FDG measures obtained from nine normal male control subjects who received no drug intervention. Results: After haloperidol administration, the haloperidol subjects showed significantly lower glucose utilization in the neocortex, limbic cortex, thalamus, and caudate nucleus but not in the putamen or cerebellum. After adjustment for global effects, significant reductions were still evident in the frontal, occipital, and anterior cingulate cortex, whereas the putamen and cerebellum showed significant increases. Conclusions: This study, measuring the brain's metabolic response to acute receptor blockade, is a first step in the development of an assay of CNS pharmacological activity. By determining the response to neuroleptic challenge in a normal state, the study establishes a comparison group for determining response to challenge in various psychiatric conditions.
AB - Objective: Positron emission tomography and the fluorodeoxyglucose (FDG) method were used to determine the brain's metabolic response to neuroleptic challenge in a normal, disease-free state. Method: FDG measurements were obtained before and 12 hours after administration of 5 mg of haloperidol to 12 young normal men. These values were compared with test-retest FDG measures obtained from nine normal male control subjects who received no drug intervention. Results: After haloperidol administration, the haloperidol subjects showed significantly lower glucose utilization in the neocortex, limbic cortex, thalamus, and caudate nucleus but not in the putamen or cerebellum. After adjustment for global effects, significant reductions were still evident in the frontal, occipital, and anterior cingulate cortex, whereas the putamen and cerebellum showed significant increases. Conclusions: This study, measuring the brain's metabolic response to acute receptor blockade, is a first step in the development of an assay of CNS pharmacological activity. By determining the response to neuroleptic challenge in a normal state, the study establishes a comparison group for determining response to challenge in various psychiatric conditions.
UR - http://www.scopus.com/inward/record.url?scp=0028288211&partnerID=8YFLogxK
U2 - 10.1176/ajp.151.5.681
DO - 10.1176/ajp.151.5.681
M3 - Article
C2 - 8166309
AN - SCOPUS:0028288211
SN - 0002-953X
VL - 151
SP - 681
EP - 686
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 5
ER -