TY - JOUR
T1 - Effects of genotype and diet on age-related lesions in Ad libitum Fed and calorie-restricted F344, BN, and BNF3F1 rats
AU - Lipman, R. D.
AU - Dallal, G. E.
AU - Bronson, R. T.
PY - 1999/11
Y1 - 1999/11
N2 - The effects of calorie restriction (CR) on age-related lesions in Brown Norway, Fischer 344, and BNFSF1 hybrid rats are presented. A logistic regression analysis of data from histologic samples from rats of each genotype, sex, and diet at 12, 18, 24, 30, and 36 months of age demonstrated the effects of age, diet, and sex on lesion prevalence in all three genotypes. CR reduced the prevalence of neoplastic, nonneoplastic proliferative, and degenerative lesions. All genotype-sex-age cohorts demonstrated a reduced average lesion burden with CR. Importantly, some lesions common to Brown Norway rats seldom occurred in Fischer 344 rats and vice versa. Some lesions that occurred in only one parental strain also occurred in BNFSF1 rats. Many traits occurred in all three genotypes but at significantly different prevalence rates. We suggest that the diseases and lesions that rats develop as they age are controlled by genes and environmental factors such as CR.
AB - The effects of calorie restriction (CR) on age-related lesions in Brown Norway, Fischer 344, and BNFSF1 hybrid rats are presented. A logistic regression analysis of data from histologic samples from rats of each genotype, sex, and diet at 12, 18, 24, 30, and 36 months of age demonstrated the effects of age, diet, and sex on lesion prevalence in all three genotypes. CR reduced the prevalence of neoplastic, nonneoplastic proliferative, and degenerative lesions. All genotype-sex-age cohorts demonstrated a reduced average lesion burden with CR. Importantly, some lesions common to Brown Norway rats seldom occurred in Fischer 344 rats and vice versa. Some lesions that occurred in only one parental strain also occurred in BNFSF1 rats. Many traits occurred in all three genotypes but at significantly different prevalence rates. We suggest that the diseases and lesions that rats develop as they age are controlled by genes and environmental factors such as CR.
UR - http://www.scopus.com/inward/record.url?scp=0033377755&partnerID=8YFLogxK
U2 - 10.1093/gerona/54.11.B478
DO - 10.1093/gerona/54.11.B478
M3 - Article
C2 - 10619311
AN - SCOPUS:0033377755
SN - 1079-5006
VL - 54
SP - B478-B491
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 11
ER -