TY - JOUR
T1 - Effects of depression and anxiety on quality of life in five common neurological disorders
AU - Prisnie, Joey C.
AU - Sajobi, Tolulope T.
AU - Wang, Meng
AU - Patten, Scott B.
AU - Fiest, Kirsten M.
AU - Bulloch, Andrew G.M.
AU - Pringsheim, Tamara
AU - Wiebe, Samuel
AU - Jette, Nathalie
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background: It is unclear whether anxiety and depression impact health-related quality of life (HRQoL) equally across neurological diseases. This study examines the association between anxiety or depression and HRQoL in select neurological disorders. Methods: HRQoL was measured using the Short Form Health Survey (SF-12) in neurological patients: epilepsy (n = 279), migraine (n = 268), multiple sclerosis (MS) (n = 222), stroke (n = 204), and Parkinson's disease (PD) (n = 224). Depression and anxiety symptoms were assessed using the Patient Health Questionnaire (PHQ-9) and Hospital Anxiety and Depression Scale (HADS-A), respectively. Multiple linear regression was used to evaluate variables associated with the SF-12 mental health component (MCS) and physical health component scores (PCS). Pratt index was used to estimate the relative importance of anxiety and depression on HRQoL. Results: Anxiety and depression had the largest contribution to PCS in stroke and to MCS in epilepsy. Overall, anxiety and depression had a larger contribution to MCS as compared to PCS, except in stroke patients. Different patterns were seen across neurological diseases, with mental health variables strongly affecting MCS in all conditions, with also a sizable contribution to PCS in migraine, MS, and stroke. Conclusions: Anxiety and depression have varying impacts on HRQoL across neurological diseases. It is important for clinicians to be aware of how these patterns differ in each condition.
AB - Background: It is unclear whether anxiety and depression impact health-related quality of life (HRQoL) equally across neurological diseases. This study examines the association between anxiety or depression and HRQoL in select neurological disorders. Methods: HRQoL was measured using the Short Form Health Survey (SF-12) in neurological patients: epilepsy (n = 279), migraine (n = 268), multiple sclerosis (MS) (n = 222), stroke (n = 204), and Parkinson's disease (PD) (n = 224). Depression and anxiety symptoms were assessed using the Patient Health Questionnaire (PHQ-9) and Hospital Anxiety and Depression Scale (HADS-A), respectively. Multiple linear regression was used to evaluate variables associated with the SF-12 mental health component (MCS) and physical health component scores (PCS). Pratt index was used to estimate the relative importance of anxiety and depression on HRQoL. Results: Anxiety and depression had the largest contribution to PCS in stroke and to MCS in epilepsy. Overall, anxiety and depression had a larger contribution to MCS as compared to PCS, except in stroke patients. Different patterns were seen across neurological diseases, with mental health variables strongly affecting MCS in all conditions, with also a sizable contribution to PCS in migraine, MS, and stroke. Conclusions: Anxiety and depression have varying impacts on HRQoL across neurological diseases. It is important for clinicians to be aware of how these patterns differ in each condition.
UR - http://www.scopus.com/inward/record.url?scp=85045759089&partnerID=8YFLogxK
U2 - 10.1016/j.genhosppsych.2018.03.009
DO - 10.1016/j.genhosppsych.2018.03.009
M3 - Article
C2 - 29684713
AN - SCOPUS:85045759089
SN - 0163-8343
VL - 52
SP - 58
EP - 63
JO - General Hospital Psychiatry
JF - General Hospital Psychiatry
ER -