Effects of cysteine proteases on the structural and mechanical properties of collagen fibers

Preety Panwar; Xin Du; Vidhu Sharma; Guillaume Lamour; Mickael Castro; Hongbin Li; Dieter Brömme

doi:10.1074/jbc.M112.419689

Effects of cysteine proteases on the structural and mechanical properties of collagen fibers

Preety Panwar, Xin Du, Vidhu Sharma, Guillaume Lamour, Mickael Castro, Hongbin Li, Dieter Brömme

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Background: Collagen macromolecules are biologically relevant substrates in tissue remodeling and bone-related diseases. Results: We investigated the action of cysteine proteases on the structural integrity and mechanical functionality of collagen fibers. Conclusion: Using ultrastructural and biochemical techniques, we present a model of collagen fiber degradation via cathepsin K. Significance: Our data provide new insights in matrix degradation and may allow new strategies to inhibit it.

Original language	English
Pages (from-to)	5940-5950
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M112.419689
State	Published - 22 Feb 2013
Externally published	Yes

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title = "Effects of cysteine proteases on the structural and mechanical properties of collagen fibers",

abstract = "Background: Collagen macromolecules are biologically relevant substrates in tissue remodeling and bone-related diseases. Results: We investigated the action of cysteine proteases on the structural integrity and mechanical functionality of collagen fibers. Conclusion: Using ultrastructural and biochemical techniques, we present a model of collagen fiber degradation via cathepsin K. Significance: Our data provide new insights in matrix degradation and may allow new strategies to inhibit it.",

author = "Preety Panwar and Xin Du and Vidhu Sharma and Guillaume Lamour and Mickael Castro and Hongbin Li and Dieter Br{\"o}mme",

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AU - Panwar, Preety

AU - Du, Xin

AU - Sharma, Vidhu

AU - Lamour, Guillaume

AU - Castro, Mickael

AU - Li, Hongbin

AU - Brömme, Dieter

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: Collagen macromolecules are biologically relevant substrates in tissue remodeling and bone-related diseases. Results: We investigated the action of cysteine proteases on the structural integrity and mechanical functionality of collagen fibers. Conclusion: Using ultrastructural and biochemical techniques, we present a model of collagen fiber degradation via cathepsin K. Significance: Our data provide new insights in matrix degradation and may allow new strategies to inhibit it.

AB - Background: Collagen macromolecules are biologically relevant substrates in tissue remodeling and bone-related diseases. Results: We investigated the action of cysteine proteases on the structural integrity and mechanical functionality of collagen fibers. Conclusion: Using ultrastructural and biochemical techniques, we present a model of collagen fiber degradation via cathepsin K. Significance: Our data provide new insights in matrix degradation and may allow new strategies to inhibit it.

UR - https://www.scopus.com/pages/publications/84874300261

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DO - 10.1074/jbc.M112.419689

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VL - 288

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EP - 5950

JO - Journal of Biological Chemistry

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Effects of cysteine proteases on the structural and mechanical properties of collagen fibers

Abstract

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