Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs

J. R. Sowers; P. K. Mohanty; M. D. Thames; D. S. Goldstein; S. Atlas

doi:10.1016/S0006-291X(88)80741-1

Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs

J. R. Sowers
, P. K. Mohanty
, M. D. Thames
, D. S. Goldstein
, S. Atlas

Research output: Contribution to journal › Article › peer-review

Abstract

This study evaluated the effects of synthetic atrial natriuretic factor (ANF) on renal hemodynamics, urinary excretion of electrolytes, norepinephrine (NE), and dopamine (DA); and renal production of renin in anesthetized dogs. Following a bolus (1 μg/kg body weight) and infusion (0.1 μg/kg/min) for 30 min, there was significant increase in urine flow (220 ± 41%), glomerular filtration rate (72 ± 14%), and urinary sodium excretion (170 ± 34%). There was a decrease in renin secretory rate and the concentration ratio of urine NE to DA following ANF was decreased (p<0.05). These data suggest that ANF decreases renal production of NE and renin.

Original language	English
Pages (from-to)	1070-1076
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	156
Issue number	3
DOIs	https://doi.org/10.1016/S0006-291X(88)80741-1
State	Published - 15 Nov 1988
Externally published	Yes

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10.1016/S0006-291X(88)80741-1

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@article{8f58adccd62b44cf854bc507d2ad1608,

title = "Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs",

abstract = "This study evaluated the effects of synthetic atrial natriuretic factor (ANF) on renal hemodynamics, urinary excretion of electrolytes, norepinephrine (NE), and dopamine (DA); and renal production of renin in anesthetized dogs. Following a bolus (1 μg/kg body weight) and infusion (0.1 μg/kg/min) for 30 min, there was significant increase in urine flow (220 ± 41\%), glomerular filtration rate (72 ± 14\%), and urinary sodium excretion (170 ± 34\%). There was a decrease in renin secretory rate and the concentration ratio of urine NE to DA following ANF was decreased (p<0.05). These data suggest that ANF decreases renal production of NE and renin.",

author = "Sowers, \{J. R.\} and Mohanty, \{P. K.\} and Thames, \{M. D.\} and Goldstein, \{D. S.\} and S. Atlas",

note = "Funding Information: We thank Ms. Carol N. Harris and Ms. Doris King for their assistance in the preparation of this manuscript, and Carolyn Fortner and Steven Yuih for their technical assistance. This grant was supported in part by HL-30506, and by a Veterans Administration Merit Grant.",

year = "1988",

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doi = "10.1016/S0006-291X(88)80741-1",

language = "English",

volume = "156",

pages = "1070--1076",

journal = "Biochemical and Biophysical Research Communications",

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publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs

AU - Sowers, J. R.

AU - Mohanty, P. K.

AU - Thames, M. D.

AU - Goldstein, D. S.

AU - Atlas, S.

N1 - Funding Information: We thank Ms. Carol N. Harris and Ms. Doris King for their assistance in the preparation of this manuscript, and Carolyn Fortner and Steven Yuih for their technical assistance. This grant was supported in part by HL-30506, and by a Veterans Administration Merit Grant.

PY - 1988/11/15

Y1 - 1988/11/15

N2 - This study evaluated the effects of synthetic atrial natriuretic factor (ANF) on renal hemodynamics, urinary excretion of electrolytes, norepinephrine (NE), and dopamine (DA); and renal production of renin in anesthetized dogs. Following a bolus (1 μg/kg body weight) and infusion (0.1 μg/kg/min) for 30 min, there was significant increase in urine flow (220 ± 41%), glomerular filtration rate (72 ± 14%), and urinary sodium excretion (170 ± 34%). There was a decrease in renin secretory rate and the concentration ratio of urine NE to DA following ANF was decreased (p<0.05). These data suggest that ANF decreases renal production of NE and renin.

AB - This study evaluated the effects of synthetic atrial natriuretic factor (ANF) on renal hemodynamics, urinary excretion of electrolytes, norepinephrine (NE), and dopamine (DA); and renal production of renin in anesthetized dogs. Following a bolus (1 μg/kg body weight) and infusion (0.1 μg/kg/min) for 30 min, there was significant increase in urine flow (220 ± 41%), glomerular filtration rate (72 ± 14%), and urinary sodium excretion (170 ± 34%). There was a decrease in renin secretory rate and the concentration ratio of urine NE to DA following ANF was decreased (p<0.05). These data suggest that ANF decreases renal production of NE and renin.

UR - https://www.scopus.com/pages/publications/0023692070

U2 - 10.1016/S0006-291X(88)80741-1

DO - 10.1016/S0006-291X(88)80741-1

M3 - Article

C2 - 2973318

AN - SCOPUS:0023692070

SN - 0006-291X

VL - 156

SP - 1070

EP - 1076

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Effects of atrial natriuretic factor on urinary concentration of catecholamines and renin secretion in dogs

Abstract

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