Effects of an Rb mutation in the mouse

Tyler Jacks; Amin Fazeli; Earlene M. Schmitt; Roderick T. Bronson; Margaret A. Goodell; Robert A. Weinberg

doi:10.1038/359295a0

Effects of an Rb mutation in the mouse

Tyler Jacks, Amin Fazeli, Earlene M. Schmitt, Roderick T. Bronson, Margaret A. Goodell, Robert A. Weinberg

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Abstract

The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

Original language	English
Pages (from-to)	295-300
Number of pages	6
Journal	Nature
Volume	359
Issue number	6393
DOIs	https://doi.org/10.1038/359295a0
State	Published - 1992
Externally published	Yes

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title = "Effects of an Rb mutation in the mouse",

abstract = "The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.",

author = "Tyler Jacks and Amin Fazeli and Schmitt, {Earlene M.} and Bronson, {Roderick T.} and Goodell, {Margaret A.} and Weinberg, {Robert A.}",

year = "1992",

doi = "10.1038/359295a0",

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AU - Fazeli, Amin

AU - Schmitt, Earlene M.

AU - Bronson, Roderick T.

AU - Goodell, Margaret A.

AU - Weinberg, Robert A.

PY - 1992

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N2 - The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

AB - The retinoblastoma gene is mutated in several types of human cancer and is the best characterized of the tumour-suppressor genes. A mouse strain has been constructed in which one allele of Rb is disrupted. These heterozygous animals are not predisposed to retinoblastoma, but some display pituitary tumours arising from cells in which the wild-type Rb allele is absent. Embryos homozygous for the mutation die between days 14 and 15 of gestation, exhibiting neuronal cell death and defective erythropoiesis.

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Effects of an Rb mutation in the mouse

Abstract

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